NCIt definition : The sodium salt of atorvastatin, a synthetic lipid-lowering agent. Atorvastatin competitively
inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme
which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol
synthesis. This agent increases the number of LDL receptors on hepatic cell surfaces,
enhancing the uptake and catabolism of LDL and reducing LDL production and the number
of LDL particles, and lowers plasma cholesterol and lipoprotein levels. Like other
statins, atorvastatin may also display direct antineoplastic activity, possibly by
inhibiting farnesylation and geranylgeranylation of proteins such as small GTP-binding
proteins, which may result in the arrest of cells in the G1 phase of the cell cycle.
This agent may also sensitize tumor cells to cyctostatic drugs, possibly through the
mTOR-dependent inhibition of Akt phosphorylation.;
UNII : DN43058TIV;
InChIKey : VVRPOCPLIUDBSA-CNZCJKERSA-M;
CAS number : 134523-01-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 134523-01-6
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