Preferred Label : Atorvastatin Calcium;
NCIt synonyms : Atorvastatin;
NCIt related terms : ATORVASTATIN CALCIUM TRIHYDRATE; Lipitor;
NCIt definition : The calcium salt of atorvastatin, a synthetic lipid-lowering agent. Atorvastatin competitively
inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme
which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol
synthesis. This agent increases the number of LDL receptors on hepatic cell surfaces,
enhancing the uptake and catabolism of LDL and reducing LDL production and the number
of LDL particles, and lowers plasma cholesterol and lipoprotein levels. Like other
statins, atorvastatin may also display direct antineoplastic activity, possibly by
inhibiting farnesylation and geranylgeranylation of proteins such as small GTP-binding
proteins, which may result in the arrest of cells in the G1 phase of the cell cycle.
This agent may also sensitize tumor cells to cyctostatic drugs, possibly through the
mTOR-dependent inhibition of Akt phosphorylation.;
Alternative definition : NCI-GLOSS: A drug used to lower the amount of cholesterol in the blood and to prevent
stroke, heart attack, and angina (chest pain). It is also being studied in the prevention
and treatment of some types of cancer and other conditions. Atorvastatin calcium blocks
an enzyme that helps make cholesterol in the body. It also causes an increase in the
breakdown of cholesterol. It is a type of HMG-CoA reductase inhibitor and a type of
statin.;
UNII : 48A5M73Z4Q;
InChIKey : SHZPNDRIDUBNMH-NIJVSVLQSA-L;
CAS number : 134523-03-8; 344423-98-9;
Drug name : Lipitor;
Molecule name : CI-981;
Chemical formula : 2C33H34FN2O5.Ca.3H2O;
ChEBI ID : CHEBI:2911;
Codes from synonyms : 09486; CDR0000535468; CDR0000535469;
Origin ID : C28837;
UMLS CUI : C0286650;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- Validated automatic mappings to NTBT
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- chemical_or_drug_is_metabolized_by_enzyme
- chemical_or_drug_plays_role_in_biological_process
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
