Preferred Label : Lovastatin;
NCIt synonyms : Lovastatin Sodium; Monacolin K; Mevinolin; (2S)-2-Methylbutanoic Acid, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl
Ester;
NCIt related terms : Mevacor;
NCIt definition : A lactone metabolite isolated from the fungus Aspergillus terreus with cholesterol-lowering
and potential antineoplastic activities. Lovastatin is hydrolyzed to the active beta-hydroxyacid
form, which competitively inhibits 3-hydroxyl-3-methylgutarylcoenzyme A (HMG-CoA)
reductase, an enzyme involved in cholesterol biosynthesis. In addition, this agent
may induce tumor cell apoptosis and inhibit tumor cell invasiveness, possibly by inhibiting
protein farnesylation and protein geranylgeranylation, and may arrest cells in the
G1 phase of the cell cycle. The latter effect sensitizes tumor cells to the cytotoxic
effects of ionizing radiation.;
Alternative definition : NCI-GLOSS: A drug used to lower the amount of cholesterol in the blood. It is also
being studied in the prevention and treatment of some types of cancer. Lovastatin
is a type of HMG-CoA reductase inhibitor (statin).;
UNII : 9LHU78OQFD;
InChIKey : PCZOHLXUXFIOCF-BXMDZJJMSA-N;
CAS number : 75330-75-5;
Drug name : Mevacor;
Chemical formula : C24H36O5;
NSC code : 633781;
ChEBI ID : CHEBI:40303;
Codes from synonyms : 30571; CDR0000549703; NSC0633781; CDR0000584175;
Origin ID : C620;
UMLS CUI : C0024027;
See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
