lovastatin - CISMeF

Preferred Label : lovastatin;

MeSH definition : A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.;

MeSH synonym : monacolin k; 6 methylcompactin; mevinolin; 6-methylcompactin;

CISMeF synonym : 79902-41-3 (Lovastatin, 1 alpha-Isomer (without R*/S* notation));

MeSH hyponym : lovastatin, 1 alpha-Isomer (without R*/S* notation); MK-803; lovastatin, (1 alpha(S*))-Isomer; mevacor; lovastatin, 1 alpha-Isomer; MK 803; MK803; 1 alpha-Isomer Lovastatin; Lovastatin, 1 alpha Isomer; alpha-Isomer Lovastatin, 1;

MeSH CAS label : butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1alpha(R*),3alpha,7beta,8beta(2S*,4S*),8abeta))-;

MeSH Related Number : lovastatin, (1 alpha(S*))-Isomer; lovastatin, 1 alpha-Isomer; 75330-75-5 (Lovastatin); 79902-41-3 (1 alpha-isomer without R*/S* notation); 79952-44-6 ((1 alpha(S*))-isomer);

Registry Number MeSH : 75330-75-5;

Related CAS MeSH : 79952-44-6 (Lovastatin, (1 alpha(S*))-Isomer); 79902-41-3 (Lovastatin, 1 alpha-Isomer);

Wikipedia link : https://en.wikipedia.org/wiki/Lovastatin;

Is substance : O;

UNII : 9LHU78OQFD;

InChIKey : PCZOHLXUXFIOCF-BXMDZJJMSA-N;

Details

Origin ID

D008148;

UMLS CUI

C0024027;

ATC code(s)
- lovastatin [ATC Code]
- lovastatin and nicotinic acid [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
Pharmacological action(s)
- hydroxymethylglutaryl-coa reductase inhibitors [MeSH Descriptor]
Record concept(s)
- MK-803 [MeSH concept]
- lovastatin [MeSH concept]
- lovastatin, (1 alpha(S*))-Isomer [MeSH concept]
- lovastatin, 1 alpha-Isomer [MeSH concept]
- mevacor [MeSH concept]
Related MeSH Supplementary Concept(s)
- 6-(2-(8-((4-fluorobenzyl)oxy)-1,2,6,7,8,8a-hexahydro-2,6-dimethyl-1-naphthyl)ethyl)-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one [MeSH Supplementary Concept]
- 6-hydroxyisocompactin [MeSH Supplementary Concept]
- L 157012 [MeSH Supplementary Concept]
- L 647318 [MeSH Supplementary Concept]
- L 669262 [MeSH Supplementary Concept]
- dihydrocompactin [MeSH Supplementary Concept]
- dihydromevinolin [MeSH Supplementary Concept]
- dihydroxy-7-(1,2,3,5,6,7,8,8a-octahydro-3,5-dihydroxy-2,6-dimethyl-8-(2-methylbutyryloxy)naphthalen-1-yl)heptanoic acid lactone [MeSH Supplementary Concept]
- dihydroxy-7-(1,2-dihydro-2-hydroxymethyl-6-methylnaphthalen-1-yl)heptanoic acid [MeSH Supplementary Concept]
- lovastatin-niacin combination [MeSH Supplementary Concept]
- mevastatin [MeSH Supplementary Concept]
- mevinolinic acid [MeSH Supplementary Concept]
- versicorin [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing lovastatin (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Lovastatin [ICD-11 Extension code]
- Lovastatin [LOINC component]
- Lovastatin [NCIt concept]
- Lovastatin (substance) [SNOMED CT concept]
- Product containing lovastatin (medicinal product) [SNOMED CT concept]
- lovastatin [ATC Code]
- lovastatin [SNOMED Notion]
Validated automatic mappings to BTNT
- lovastatin [ATC Code]

Keyword's position in hierarchy(ies) :

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