Preferred Label : Fluvastatin Sodium;
NCIt synonyms : (3R,5S,6E)-( /-)-7-(3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl)-3,5-dihydroxy-6-heptenoic
Acid;
NCIt definition : The sodium salt of a synthetic lipid-lowering agent with potential antineoplastic
activity. Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme
A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate,
a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein
levels, and modulates immune responses through the suppression of MHC II (major histocompatibility
complex II) on interferon gamma-stimulated, antigen-presenting cells such as human
vascular endothelial cells. Through the inhibition of mevalonate synthesis, statins,
like fluvastatin, have been shown to inhibit the production of dolichol, geranylpyrophosphate
(GPP) and farnesylpyrophosphate (FPP) and the isoprenylation of the intracellular
G-proteins Ras and Rho, which may result in antiangiogenic, apoptotic, and antimetastatic
effects in susceptible tumor cell populations.;
UNII : PYF7O1FV7F;
InChIKey : ZGGHKIMDNBDHJB-RPQBTBOMSA-M;
CAS number : 93957-55-2;
Drug name : Lescol;
Chemical formula : C24H25FNO4.Na;
Codes from synonyms : 01303;
Origin ID : C29062;
UMLS CUI : C0246203;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
