" /> Fluvastatin - CISMeF





Preferred Label : Fluvastatin;

NCIt definition : A synthetic lipid-lowering agent with antilipidemic and potential antineoplastic properties. Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses through the suppression of MHC II (major histocompatibility complex II) on interferon gamma-stimulated antigen-presenting cells such as human vascular endothelial cells. Due to its anti-inflammatory effects mediated by alterations of lipid metabolism, fluvastatin may possess chemopreventive and therapeutic antineoplastic properties.;

UNII : 4L066368AS;

InChIKey : FJLGEFLZQAZZCD-JUFISIKESA-N;

CAS number : 93957-54-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 93957-54-1 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C24H26FNO4;

ChEBI ID : CHEBI:38561; CHEBI:5136;

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15/05/2024


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