Fluvastatin - CISMeF

Preferred Label : Fluvastatin;

NCIt definition : A synthetic lipid-lowering agent with antilipidemic and potential antineoplastic properties. Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses through the suppression of MHC II (major histocompatibility complex II) on interferon gamma-stimulated antigen-presenting cells such as human vascular endothelial cells. Due to its anti-inflammatory effects mediated by alterations of lipid metabolism, fluvastatin may possess chemopreventive and therapeutic antineoplastic properties.;

UNII : 4L066368AS;

InChIKey : FJLGEFLZQAZZCD-JUFISIKESA-N;

CAS number : 93957-54-1;

Chemical formula : C24H26FNO4;

ChEBI ID : CHEBI:38561; CHEBI:5136;

Details

Origin ID

C61768;

UMLS CUI

C0082608;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Fluvastatin [MeSH Descriptor]
- Fluvastatin [LOINC component]
- Fluvastatin (substance) [SNOMED CT concept]
- Product containing fluvastatin (medicinal product) [SNOMED CT concept]
- fluvastatin [ATC Code]
- fluvastatin [SNOMED Notion]
- fluvastatin [MeSH concept]
Validated automatic mappings to BTNT
- fluvastatin [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Fluvastatin Sodium [NCIt concept]
is_free_acid_or_base_form_of
- Fluvastatin Sodium [NCIt concept]

Keyword's position in hierarchy(ies) :

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