7-(7-((1,1'-biphenyl-4-yl)methyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl)-3,5-dihydroxy-6-heptenoic acid

Preferred Label : 7-(7-((1,1'-biphenyl-4-yl)methyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl)-3,5-dihydroxy-6-heptenoic acid;

MeSH note : the sodium salt is about 3 times more potent than lovastatin sodium salt; RN given refers to the (3(3S*,5R*,6E),7R*)-isomer; structure in first source;

CISMeF synonym : biPhMe-TIDHA sodium;

MeSH Related Number : 7-(7-((1,1'-biphenyl-4-yl)methyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl)-3,5-dihydroxy-6-heptenoic acid, sodium salt, (7S-(3(3S*,5R*,6E),7R*))-isomer; 7-(7-((1,1'-biphenyl-4-yl)methyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl)-3,5-dihydroxy-6-heptenoic acid, (3(3R*,5S*,6E),7R*)-isomer; 7-(7-((1,1'-biphenyl-4-yl)methyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl)-3,5-dihydroxy-6-heptenoic acid, sodium salt, (7R-(3(3R*,5S*,6E),7R*))-isomer; 153220-25-8 ((7S-(3(3S*,5R*,6E),7R*))-isomer na salt); 153220-26-9 ((7R-(3(3R*,5S*,6E),7R*))-isomer na salt); 153321-51-8 ((3(3R*,5S*,6E),7R*)-isomer);

Registry Number MeSH : 153321-50-7;

Related CAS MeSH : 153220-25-8 (7-(7-((1,1'-biphenyl-4-yl)methyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl)-3,5-dihydroxy-6-heptenoic acid, sodium salt, (7S-(3(3S*,5R*,6E),7R*))-isomer); 153321-51-8 (7-(7-((1,1'-biphenyl-4-yl)methyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl)-3,5-dihydroxy-6-heptenoic acid, (3(3R*,5S*,6E),7R*)-isomer); 153220-26-9 (7-(7-((1,1'-biphenyl-4-yl)methyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl)-3,5-dihydroxy-6-heptenoic acid, sodium salt, (7R-(3(3R*,5S*,6E),7R*))-isomer);

related registry number list (CISMeF) : 153220-25-8 ((7S-(3(3S*,5R*,6E),7R*))-isomer Na salt); 153220-26-9 ((7R-(3(3R*,5S*,6E),7R*))-isomer Na salt); 153321-51-8 ((3(3R*,5S*,6E),7R*)-isomer);

Is substance : O;

Details

Origin ID

C084472;

UMLS CUI

C0662668;

MeSH indexing information
- hydroxymethylglutaryl CoA reductases [MeSH Descriptor]
MeSH term(s) associated for indexing
- hydroxy acids [MeSH Descriptor]
- indazoles [MeSH Descriptor]
Pharmacological action(s)
- hydroxymethylglutaryl-coa reductase inhibitors [MeSH Descriptor]
Record concept(s)
- 7-(7-((1,1'-biphenyl-4-yl)methyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl)-3,5-dihydroxy-6-heptenoic acid [MeSH concept]
- 7-(7-((1,1'-biphenyl-4-yl)methyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl)-3,5-dihydroxy-6-heptenoic acid, (3(3R*,5S*,6E),7R*)-isomer [MeSH concept]
- 7-(7-((1,1'-biphenyl-4-yl)methyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl)-3,5-dihydroxy-6-heptenoic acid, sodium salt, (7R-(3(3R*,5S*,6E),7R*))-isomer [MeSH concept]
- 7-(7-((1,1'-biphenyl-4-yl)methyl)-2-(4-fluorophenyl)-4,5,6,7-tetrahydro-2H-indazol-3-yl)-3,5-dihydroxy-6-heptenoic acid, sodium salt, (7S-(3(3S*,5R*,6E),7R*))-isomer [MeSH concept]
- biPhMe-TIDHA sodium [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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