HMG-CoA Reductase Inhibitor

Preferred Label : HMG-CoA Reductase Inhibitor;

NCIt synonyms : Hydroxymethylglutaryl CoenzymeA Reductase Inhibitors;

NCIt related terms : hydroxymethylglutaryl-coenzyme A reductase inhibitor; statin;

NCIt definition : Any substance that inhibits HMG-CoA reductase, a key enzyme in cholesterol synthesis. Inhibition of HMG-CoA reductase acts to lower plasma cholesterol and lipoprotein levels.;

Alternative definition : NCI-GLOSS: Any of a group of drugs that lower the amount of cholesterol and certain fats in the blood. Statins inhibit a key enzyme that helps make cholesterol. Statin drugs are being studied in the prevention and treatment of cancer.; ACC/AHA: An HMG-CoA reductase inhibitor (statin). Lipid-lowering medications with proven ASCVD benefits.;

ChEBI ID : CHEBI:35664;

Codes from synonyms : CDR0000390255; CDR0000430880; CDR0000430881;

Details

Origin ID

C1655;

UMLS CUI

C0360714;

Automatic exact mappings (from CISMeF team)
- 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (disposition) [SNOMED CT concept]
- Administration of prophylactic statin (procedure) [SNOMED CT concept]
- statine [MeSH concept]
- statine [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- Hydroxymethylglutaryl-CoA reductase inhibitors [MeSH concept]
- Product containing 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (product) [SNOMED CT concept]
- Substance with 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor mechanism of action (substance) [SNOMED CT concept]
- hmg coa reductase inhibitors [ATC Code]
- hmg-coa reductase inhibitor, nos [SNOMED Notion]
- hydroxymethylglutaryl-coa reductase inhibitors [MeSH Descriptor]
- statins [MedlinePlus Topic]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Hydroxymethylglutaryl-CoA reductase inhibitors [MeSH concept]
- Product containing 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (product) [SNOMED CT concept]
- Substance with 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor mechanism of action (substance) [SNOMED CT concept]
- hmg-coa reductase inhibitor, nos [SNOMED Notion]
- hydroxymethylglutaryl-coa reductase inhibitors [MeSH Descriptor]
- statins [MedlinePlus Topic]
concept_is_in_subset
- ACC/AHA COVID-19 Appendix Variables [NCIt concept]
- ACC/AHA Cardiovascular and Noncardiovascular Complications of COVID-19 Terminology [NCIt concept]
- Appendix 8: Pharmacological Therapy Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- Therapies for Preexisting Cardiovascular Disease (Patient Taking Prior to Admission) Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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