meglutol - CISMeF

Preferred Label : meglutol;

MeSH definition : An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol.;

MeSH synonym : acid, 3-hydroxy-3-methylpentanedioic; 3 hydroxy 3 methylglutaric acid; beta-hydroxy-beta-methylglutarate; beta hydroxy beta methylglutarate; 3-hydroxy-3-methylpentanedioic acid; acid, 3-hydroxy-3-methylglutaric; 3 hydroxy 3 methylpentanedioic acid; 3-hydroxy-3-methylglutaric acid;

MeSH CAS label : pentanedioic acid, 3-hydroxy-3-methyl-;

MeSH Related Number : 503-49-1 (Meglutol);

Registry Number MeSH : 503-49-1;

Codes EINECS : 207-971-1;

Is substance : O;

UNII : CLA99KCD53;

InChIKey : NPOAOTPXWNWTSH-UHFFFAOYSA-N;

Details

Origin ID

D015093;

UMLS CUI

C0000402;

ATC code(s)
- meglutol [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
CISMeF manual mappings
- meglutol [Substance BNPC]
Currated CISMeF NLP mapping
- Meglutol [NCIt concept]
Pharmacological action(s)
- hydroxymethylglutaryl-coa reductase inhibitors [MeSH Descriptor]
Record concept(s)
- meglutol [MeSH concept]
Related MeSH Supplementary Concept(s)
- 3-hydroxy-3-ethylglutaric acid [MeSH Supplementary Concept]
- 3-hydroxy-3-methylglutaric anhydride [MeSH Supplementary Concept]
- 3-methylglutaric acid [MeSH Supplementary Concept]
- gymnopilin 1 [MeSH Supplementary Concept]
- gymnopilin 2 [MeSH Supplementary Concept]
- gymnopilin 3 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Meglutol [NCIt concept]
- meglutol [ATC Code]
- meglutol [Substance BNPC]
Validated automatic mappings to BTNT
- meglutol [ATC Code]

Keyword's position in hierarchy(ies) :

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