Preferred Label : Zoledronic Acid;
MeSH definition : An imidodiphosphonate and inhibitor of BONE RESORPTION that is used for the treatment
of malignancy-related HYPERCALCEMIA; OSTEITIS DEFORMANS; and OSTEOPOROSIS.; An imidobisphosphonate inhibitor of BONE RESORPTION that is used for the treatment
of malignancy-related HYPERCALCEMIA; OSTEITIS DEFORMANS; and OSTEOPOROSIS.;
MeSH synonym : 2-(Imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid;
MeSH hyponym : CGP-42446; CGP 42446; CGP42446; CGP-42'446; CGP42'446; CGP 42'446;
MeSH Related Number : 118072-93-8 (Anhydrous); 158859-43-9 (CGP 42446A); 70HZ18PH24;
Wikipedia link : https://en.wikipedia.org/wiki/Zoledronic acid;
UNII : 6XC1PAD3KF;
Origin ID : D000077211;
UMLS CUI : C0257685;
ATC code(s)
ATC code(s)
Allowable qualifiers
CISMeF manual mappings
Pharmacological action(s)
Record concept(s)
Semantic type(s)
An imidodiphosphonate and inhibitor of BONE RESORPTION that is used for the treatment
of malignancy-related HYPERCALCEMIA; OSTEITIS DEFORMANS; and OSTEOPOROSIS.
An imidobisphosphonate inhibitor of BONE RESORPTION that is used for the treatment
of malignancy-related HYPERCALCEMIA; OSTEITIS DEFORMANS; and OSTEOPOROSIS.
https://www.has-sante.fr/jcms/p_3549253/fr/acide-zoledronique-tillomed-acide-zoledronique-complications-osseuses-et-hypercalcemie
2024
false
false
false
France
insurance, health, reimbursement
treatment outcome
zoledronic acid
bone density conservation agents
infusions, intravenous
drugs, generic
adult
fractures, spontaneous
Hypercalcemia of Malignancy
neoplasms
hypercalcemia
spinal cord compression
Hypercalcemia of Malignancy
hypercalcemia
evaluation of the transparency committee
Zoledronic Acid
---
http://www.has-sante.fr/portail/jcms/c_1751307/fr/les-medicaments-de-losteoporose
2023
false
true
false
France
French
bone density conservation agents
osteoporosis
treatment outcome
alendronic acid
alendronate
guidelines for drug use
zoledronic acid
administration, oral
risedronic acid
denosumab
Raloxifene Hydrochloride
strontium ranelate
strontium ranelate
teriparatide
teriparatide
spinal fractures
hip fractures
costs and cost analysis
bone density conservation agents
drug costs
bone density
risk
osteoporosis, postmenopausal
adrenal cortex hormones
osteoporosis
osteoporotic fractures
alendronic acid and colecalciferol
drugs, generic
infusions, intravenous
risedronic acid, calcium and colecalciferol, sequential
injections, subcutaneous
raloxifene
algorithms
Adrenocortical steroid therapy
corticosteroid therapy
Risedronic Acid
Denosumab
diphosphonates
imidazoles
organometallic compounds
thiophenes
Zoledronic Acid
---
https://ansm.sante.fr/tableau-marr/acide-zoledronique
2022
false
false
false
France
French
risk management
patients guideline
guidelines for drug use
Zoledronic Acid
Drug-Related side effects and adverse reactions
bone density conservation agents
Bisphosphonate-Associated osteonecrosis of the jaw
risk
zoledronic acid
---
http://www.lecrat.eu/?s=Acide+zol%C3%A9dronique
France
drug information
zoledronic acid
pregnancy, nos
teratogens
pregnancy, high-risk
Zoledronic Acid
---
http://www.has-sante.fr/portail/jcms/c_2621683/fr/aclasta
2016
true
France
French
osteitis deformans
treatment outcome
male osteoporosis
osteoporosis, postmenopausal
osteoporosis
bone density conservation agents
diphosphonates
imidazoles
injections, intravenous
zoledronic acid
evaluation of the transparency committee
Zoledronic Acid
---
http://www.meddispar.fr/Medicaments/ACIDE-ZOLEDRONIQUE-TEVA-PHARMA-5-B-1/(type)/letter/(value)/A/(cip)/3400926883775
2014
false
false
false
France
French
drug information
zoledronic acid
soil
soil
diphosphonates
imidazoles
Zoledronic Acid
---
http://www.meddispar.fr/Medicaments/ACIDE-ZOLEDRONIQUE-KABI-4-B-1/(type)/letter/(value)/A/(cip)/3400926699543
2014
false
true
false
France
French
drug information
zoledronic acid
drugs, generic
drug prescriptions
legislation, drug
infusions, intravenous
continuity of patient care
drug monitoring
diphosphonates
imidazoles
Zoledronic Acid
---
https://www.ema.europa.eu/medicines/human/EPAR/Zoledronic-Acid-Accord
2014
false
false
false
United Kingdom
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
drug approval
europe
zoledronic acid
adult
drugs, generic
bone density conservation agents
bone density conservation agents
bone neoplasms
fractures, bone
spinal cord compression
hypercalcemia
infusions, intravenous
neoplasms
aged
drug interactions
renal insufficiency
pregnancy
breast feeding
fertility
drug evaluation, preclinical
diphosphonates
imidazoles
diphosphonates
imidazoles
Zoledronic Acid
Zoledronic Acid
---
http://www.meddispar.fr/Medicaments/ACIDE-ZOLEDRONIQUE-SANDOZ-4-B-1/(type)/letter/(value)/A/(cip)/3400922408897
2014
drug information
zoledronic acid
soil
Zoledronic Acid
---
http://www.meddispar.fr/Medicaments/ACIDE-ZOLEDRONIQUE-BIOGARAN-5-B-1/(type)/letter/(value)/A/(cip)/3400927576645
2014
drug information
zoledronic acid
soil
Zoledronic Acid
---
http://www.inesss.qc.ca/fileadmin/doc/INESSS/Rapports/Medicaments/INESSS_Portrait_usage_osteoporose.pdf
2014
false
false
false
Canada
French
technical report
adult
aged
diphosphonates
osteoporotic fractures
alendronate
bone density conservation agents
imidazoles
medication adherence
vitamin D
calcium
calcium, dietary
osteoporosis
Risedronic Acid
Denosumab
Zoledronic Acid
---
https://www.ema.europa.eu/medicines/human/EPAR/Zometa
2013
United Kingdom
English
French
syndication feed
drug evaluation
diphosphonates
imidazoles
bone density conservation agents
hypercalcemia
bone neoplasms
treatment outcome
imidazoles
diphosphonates
bone density conservation agents
bone resorption
zoledronic acid
diphosphonates
neoplasms
drug evaluation
summary of product characteristics
package leaflet
fractures, spontaneous
spinal cord compression
hypercalcemia
Zoledronic Acid
---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=64044205
2013
summary of product characteristics
zoledronic acid
Zoledronic Acid
---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=66953992
2013
summary of product characteristics
zoledronic acid
Zoledronic Acid
---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=68737947
2013
summary of product characteristics
zoledronic acid
Zoledronic Acid
---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=68011537
2013
summary of product characteristics
zoledronic acid
Zoledronic Acid
---
http://www.has-sante.fr/portail/jcms/c_1701315/fr/zometa
http://www.has-sante.fr/portail/jcms/c_1701314/fr/zometa06112013avisct12958
http://www.has-sante.fr/portail/jcms/c_981921/fr/zometa
http://www.has-sante.fr/portail/jcms/c_399784/fr/zometa-4-mg-poudre-et-solvant-pour-solution-pour-perfusion-boite-de-1
http://www.has-sante.fr/portail/jcms/c_399290/fr/zometa-4-mg-poudre-et-solvant-pour-solution-pour-perfusion-boite-de-1-4-et-10?xtmc=&xtcr=4
2013
France
French
evaluation of the transparency committee
bone density conservation agents
diphosphonates
imidazoles
zoledronic acid
infusions, intravenous
insurance, health, reimbursement
neoplasms
hypercalcemia
adult
bone neoplasms
bone neoplasms
fractures, spontaneous
spinal cord compression
Zoledronic Acid
---
http://www.meddispar.fr/Medicaments/ACIDE-ZOLEDRONIQUE-HOSPIRA-4-B-1/(type)/letter/(value)/A/(cip)/3400926878344
2013
France
French
drug information
drugs, generic
continuity of patient care
drug monitoring
infusions, intravenous
zoledronic acid
legislation, drug
drug prescriptions
diphosphonates
imidazoles
Zoledronic Acid
---
http://www.meddispar.fr/Medicaments/ACIDE-ZOLEDRONIQUE-KABI-4-B-1/%28type%29/letter/%28value%29/A/%28cip%29/3400926699543
2013
France
French
diphosphonates
imidazoles
continuity of patient care
drugs, generic
drug prescriptions
legislation, drug
zoledronic acid
drug monitoring
infusions, intravenous
drug information
Zoledronic Acid
---
http://www.has-sante.fr/portail/jcms/c_1648969/fr/acide-zoledronique-resolute
http://www.has-sante.fr/portail/jcms/c_1648968/fr/acide-zoledronique-resolute-18092013-avis-ct13122
2013
France
French
evaluation of the transparency committee
drugs, generic
insurance, health, reimbursement
Zoledronic acid 800mcg/mL injection 5mL vial (product)
bone density conservation agents
infusions, intravenous
hypercalcemia
bone neoplasms
spinal cord compression
fractures, spontaneous
bone neoplasms
adult
zoledronic acid
hypercalcemia
neoplasms
diphosphonates
imidazoles
Zoledronic Acid
---
https://www.ema.europa.eu/medicines/human/EPAR/Zoledronic-acid-Teva-Pharma
2013
France
French
English
drug approval
europe
treatment outcome
drugs, generic
infusions, intravenous
zoledronic acid
osteitis deformans
adult
osteoporosis, postmenopausal
fractures, bone
summary of product characteristics
package leaflet
drug evaluation
syndication feed
bone density conservation agents
bone density conservation agents
drug interactions
pregnancy
breast feeding
fertility
drug evaluation, preclinical
diphosphonates
diphosphonates
imidazoles
imidazoles
Zoledronic Acid
Zoledronic Acid
---
http://www.meddispar.fr/Medicaments/ZOMETA-4-B-1/(type)/letter/(value)/Z/(cip)/3400921752649
2012
France
French
drug information
zoledronic acid
legislation, drug
drug prescriptions
infusions, intravenous
drug monitoring
diphosphonates
imidazoles
Zoledronic Acid
---
https://www.ema.europa.eu/medicines/human/EPAR/Aclasta
2012
United Kingdom
French
English
syndication feed
diphosphonates
imidazoles
bone density conservation agents
diphosphonates
imidazoles
bone density conservation agents
osteitis deformans
zoledronic acid
diphosphonates
imidazoles
osteoporosis, postmenopausal
osteoporosis
osteoporotic fractures
risk
hip fractures
osteoporosis
drug evaluation
summary of product characteristics
package leaflet
Zoledronic Acid
Zoledronic Acid
---
https://www.ema.europa.eu/medicines/human/EPAR/Zoledronic-Acid-Hospira
2012
United Kingdom
French
English
drug approval
europe
treatment outcome
infusions, intravenous
drugs, generic
zoledronic acid
bone density conservation agents
bone density conservation agents
adult
bone neoplasms
fractures, bone
spinal cord compression
hypercalcemia
fertility
pregnancy
breast feeding
drug interactions
drug evaluation, preclinical
osteoporosis
osteoporotic fractures
summary of product characteristics
package leaflet
drug evaluation
syndication feed
risk
osteitis deformans
bone resorption
bone neoplasms
diphosphonates
diphosphonates
imidazoles
imidazoles
Zoledronic Acid
Zoledronic Acid
---
https://www.ema.europa.eu/medicines/human/EPAR/Zoledronic-acid-Mylan
2012
false
United Kingdom
English
French
package leaflet
summary of product characteristics
drug evaluation
syndication feed
diphosphonates
diphosphonates
imidazoles
imidazoles
drug approval
treatment outcome
drugs, generic
bone density conservation agents
bone density conservation agents
infusions, intravenous
adult
breast feeding
fertility
pregnancy
fractures, bone
spinal cord compression
hypercalcemia
drug interactions
bone resorption
bone neoplasms
bone diseases
zoledronic acid
Zoledronic Acid
Zoledronic Acid
---
https://www.ema.europa.eu/medicines/human/EPAR/Zoledronic-acid-Teva
2012
United Kingdom
French
English
summary of product characteristics
package leaflet
drug evaluation
syndication feed
infusions, intravenous
adult
bone density conservation agents
bone density conservation agents
bone neoplasms
Neoplasms, Bone Tissue
fractures, bone
spinal cord compression
breast feeding
fertility
pregnancy
drug interactions
hypercalcemia
bone resorption
drug evaluation, preclinical
diphosphonates
diphosphonates
imidazoles
imidazoles
drug approval
treatment outcome
zoledronic acid
drugs, generic
Zoledronic Acid
Zoledronic Acid
---
https://www.ema.europa.eu/medicines/human/EPAR/Zoledronic-acid-Actavis
2012
United Kingdom
French
English
summary of product characteristics
package leaflet
drug evaluation
syndication feed
Zoledronic acid hydrate (substance)
drugs, generic
infusions, intravenous
drug approval
treatment outcome
adult
bone density conservation agents
bone density conservation agents
zoledronic acid
bone neoplasms
Neoplasms, Bone Tissue
fractures, bone
hypercalcemia
spinal cord compression
drug interactions
pregnancy
breast feeding
bone resorption
drug evaluation, preclinical
fertility
diphosphonates
diphosphonates
imidazoles
imidazoles
Zoledronic Acid
Zoledronic Acid
---
https://www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2010/14065a-fra.php
https://www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2010/14585a-fra.php
2010
Canada
English
French
diphosphonates
imidazoles
bone density conservation agents
zoledronic acid
infusions, intravenous
renal insufficiency
diphosphonates
imidazoles
pharmacovigilance note
patient education handout
Zoledronic Acid
---
http://www.has-sante.fr/portail/jcms/c_921631/aclasta-acide-zoledronique-bisphosphonate-par-voie-iv
2010
France
evaluation of the transparency committee
zoledronic acid
Zoledronic Acid
---
http://www.has-sante.fr/portail/jcms/c_813445/aclasta-acide-zoledronique-bisphosphonate-par-voie-iv
http://www.has-sante.fr/portail/jcms/c_799087/aclasta-ct-6147
2009
France
French
osteoporosis, postmenopausal
osteoporosis
bone density conservation agents
diphosphonates
imidazoles
injections, intravenous
zoledronic acid
diphosphonates
imidazoles
guidelines for drug use
evaluation of the transparency committee
Zoledronic Acid
---
https://cadth.ca/sites/default/files/cdr/complete/cdr_complete_Aclasta_july-08_f.pdf
2008
Canada
French
bone density conservation agents
diphosphonates
imidazoles
osteoporosis, postmenopausal
canada
treatment outcome
osteitis deformans
fractures, bone
infusions, intravenous
insurance, health, reimbursement
drug costs
zoledronic acid
diphosphonates
imidazoles
drug evaluation
Zoledronic Acid
---
https://www.has-sante.fr/jcms/r_1439939
2008
true
France
French
diphosphonates
imidazoles
bone density conservation agents
osteoporosis, postmenopausal
injections, intravenous
zoledronic acid
guidelines for drug use
Zoledronic Acid
Zoledronic Acid
---
http://www.meddispar.fr/medicaments/3658711
2008
France
French
imidazoles
drug prescriptions
legislation, drug
diphosphonates
continuity of patient care
infusions, parenteral
zoledronic acid
drug information
Zoledronic Acid
---
https://minerva-ebp.be/fr/article/588
2007
false
minerva-ebm.be
Belgium
French
osteoporosis, postmenopausal
imidazoles
diphosphonates
imidazoles
diphosphonates
fractures, bone
drug evaluation
diphosphonates
imidazoles
critical appraisal or critical reading
Zoledronic Acid
---
https://www.amub-ulb.be/system/files/rmb/old/216
2005
Belgium
French
osteitis deformans
diphosphonates
imidazoles
bone density conservation agents
diphosphonates
imidazoles
journal article
Zoledronic Acid
---