Terfenadine - CISMeF

Preferred Label : Terfenadine;

NCIt definition : A prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects. Terfenadine's active metabolite competitively binds peripheral H1-receptors, thereby stabilizing an inactive conformation of the receptor. Consequently, usual allergic responses as a result of mast-cell degranulation followed by the release of multiple inflammatory mediators, such as interleukins, prostaglandins, and leukotriene precursors, are blocked, thereby preventing the triggering of pro-inflammatory pathways.;

UNII : 7BA5G9Y06Q;

InChIKey : GUGOEEXESWIERI-UHFFFAOYSA-N;

CAS number : 50679-08-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 50679-08-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Seldane; Teldane;

Chemical formula : C32H41NO2;

NSC code : 665802;

Codes from synonyms : 20184;

Details

Origin ID

C29494;

UMLS CUI

C0085173;

Currated CISMeF NLP mapping
- Terfenadine [ICD-11 Extension code]
- Terfenadine [LOINC component]
- Terfenadine (substance) [SNOMED CT concept]
- terfenadine [Substance BNPC]
- terfenadine [MeSH Descriptor]
- terfenadine [MeSH concept]
- terfenadine [SNOMED Notion]
False automatic mappings
- Product containing terfenadine (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing terfenadine (medicinal product) [SNOMED CT concept]
- Terfenadine [ICD-11 Extension code]
- Terfenadine [LOINC component]
- Terfenadine (substance) [SNOMED CT concept]
- terfenadine [ATC Code]
- terfenadine [Substance BNPC]
- terfenadine [MeSH concept]
- terfenadine [SNOMED Notion]
- terfenadine [MeSH Descriptor]
Validated automatic mappings to BTNT
- terfenadine [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
- Cytochrome P450 3A5 [NCIt concept]
- Cytochrome P450 3A7 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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