Nisoldipine - CISMeF

Preferred Label : Nisoldipine;

NCIt synonyms : Nisoldipine SR;

NCIt definition : A dihydropyridine calcium channel blocking agent. Nisoldipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04);

UNII : 4I8HAB65SZ;

InChIKey : VKQFCGNPDRICFG-UHFFFAOYSA-N;

CAS number : 63675-72-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 63675-72-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Sular;

Chemical formula : C20H24N2O6;

Codes from synonyms : 30476;

Details

Origin ID

C29291;

UMLS CUI

C0028116;

Automatic exact mappings (from CISMeF team)
- Nisoldipine [ICHI extension code]
See also inter- (CISMeF)
- Product containing nisoldipine (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Nisoldipine [ICD-11 Extension code]
- Nisoldipine (substance) [SNOMED CT concept]
- Product containing nisoldipine (medicinal product) [SNOMED CT concept]
- nisoldipine [ATC Code]
- nisoldipine [Substance BNPC]
- nisoldipine [MeSH concept]
- nisoldipine [MeSH Descriptor]
Validated automatic mappings to BTNT
- nisoldipine [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
- Cytochrome P450 3A5 [NCIt concept]
- Cytochrome P450 3A7 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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