Clarithromycin

Preferred Label : Clarithromycin;

NCIt synonyms : Abbott-56268; 6-O-Methylerythromycin;

NCIt definition : A semisynthetic 14-membered ring macrolide antibiotic. Clarithromycin binds to the 50S ribosomal subunit and inhibits RNA-dependent protein synthesis in susceptible organisms. Clarithromycin has been shown to eradicate gastric MALT (mucosa-associated lymphoid tissue) lymphomas, presumably due to the eradication of tumorigenic Helicobacter pylori infection. This agent also acts as a biological response modulator, possibly inhibiting angiogenesis and tumor growth through alterations in growth factor expression. (NCI04);

Alternative definition : NCI-GLOSS: An antibiotic drug used to treat infection. It belongs to the family of drugs called macrolides.;

UNII : H1250JIK0A;

InChIKey : AGOYDEPGAOXOCK-KCBOHYOISA-N;

CAS number : 81103-11-9;

Drug name : Biaxin;

Chemical formula : C38H69NO13;

NSC code : 643733;

ChEBI ID : CHEBI:3732;

Codes from synonyms : NSC0643733; CDR0000045449; 09601; 108;

Details

Origin ID

C1054;

UMLS CUI

C0055856;

Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Clarithromycin [LOINC component]
- Clarithromycin (substance) [SNOMED CT concept]
- Product containing clarithromycin (medicinal product) [SNOMED CT concept]
- clarithromycin [ATC Code]
- clarithromycin [Substance BNPC]
- clarithromycin [SNOMED Notion]
- clarithromycin [MeSH concept]
- clarithromycin [MeSH Descriptor]
Validated automatic mappings to BTNT
- clarithromycin [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
- Cytochrome P450 3A5 [NCIt concept]
- Cytochrome P450 3A7 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Amoxicillin/Clarithromycin/Omeprazole [NCIt concept]
- BLT-D Regimen [NCIt concept]
- BiRd Regimen [NCIt concept]
- Clarithromycin/Omeprazole/Tinidazole [NCIt concept]

Keyword's position in hierarchy(ies) :

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