Domperidone - CISMeF

Preferred Label : Domperidone;

NCIt related terms : Motilium; KW 5338; R 33,812;

NCIt definition : A peripheral-specific antagonist of the dopamine receptor D2 (D2R), with antiemetic, gastrokinetic and galactagogue activities. Following administration, domperidone binds to D2R expressed by peripheral neurons; this inhibits dopamine binding and D2R-mediated signaling. Inhibition of peripheral D2R signaling prevents or relieves various gastrointestinal (GI) symptoms, such as nausea and vomiting, and may help relief reflux and symptoms of a variety of other upper GI disorders.;

UNII : 5587267Z69;

InChIKey : FGXWKSZFVQUSTL-UHFFFAOYSA-N;

CAS number : 57808-66-9;

Drug name : Motilium;

Molecule name : R 33,812; KW 5338;

Chemical formula : C22H24ClN5O2;

NSC code : 299589;

ChEBI ID : CHEBI:31515;

Codes from synonyms : NSC0299589; 167;

Details

Origin ID

C454;

UMLS CUI

C0013015;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Domperidone [ICD-11 Extension code]
- Domperidone [LOINC component]
- Domperidone (substance) [SNOMED CT concept]
- Product containing domperidone (medicinal product) [SNOMED CT concept]
- domperidone [ATC Code]
- domperidone [Substance BNPC]
- domperidone [SNOMED Notion]
- domperidone [MeSH Descriptor]
- domperidone [MeSH concept]
Validated automatic mappings to BTNT
- domperidone [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
- Cytochrome P450 3A5 [NCIt concept]
- Cytochrome P450 3A7 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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