NCIt definition : A triazolobenzodiazepine agent with anxiolytic, sedative-hypnotic and anticonvulsant
activities. Alprazolam binds to a specific site distinct from the inhibitory neurotransmitter
gamma-aminobutyric acid (GABA) binding site on the benzodiazepine-GABA-A-chloride
ionophore receptor complex located in the limbic, thalamic and hypothalamic regions
of the central nervous system (CNS). This binding causes an allosteric modification
of the receptor and enhances the affinity of GABA to the receptor leading to an increase
in the frequency of chloride-channel opening events. This leads to an increase in
chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential
and leads to a decrease in neuronal excitability.;
Alternative definition : NCI-GLOSS: A drug used to treat anxiety disorders and panic attacks. It is being studied
in the treatment of nausea and vomiting caused by some cancer treatments. It is a
type of benzodiazepine.;
UNII : YU55MQ3IZY;
InChIKey : VREFGVBLTWBCJP-UHFFFAOYSA-N;
CAS number : 28981-97-7;
Drug name : Nu-Alpraz; Apo-Alpzar; Xanax;
Chemical formula : C17H13ClN4;
ChEBI ID : CHEBI:2611;
Codes from synonyms : CDR0000572134; CDR0000476309; 22;