Alprazolam - CISMeF

Preferred Label : Alprazolam;

NCIt related terms : Xanax;

NCIt definition : A triazolobenzodiazepine agent with anxiolytic, sedative-hypnotic and anticonvulsant activities. Alprazolam binds to a specific site distinct from the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) binding site on the benzodiazepine-GABA-A-chloride ionophore receptor complex located in the limbic, thalamic and hypothalamic regions of the central nervous system (CNS). This binding causes an allosteric modification of the receptor and enhances the affinity of GABA to the receptor leading to an increase in the frequency of chloride-channel opening events. This leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential and leads to a decrease in neuronal excitability.;

Alternative definition : NCI-GLOSS: A drug used to treat anxiety disorders and panic attacks. It is being studied in the treatment of nausea and vomiting caused by some cancer treatments. It is a type of benzodiazepine.;

UNII : YU55MQ3IZY;

InChIKey : VREFGVBLTWBCJP-UHFFFAOYSA-N;

CAS number : 28981-97-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 28981-97-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Nu-Alpraz; Apo-Alpzar; Xanax;

Chemical formula : C17H13ClN4;

ChEBI ID : CHEBI:2611;

Codes from synonyms : CDR0000572134; CDR0000476309; 22;

Details

Origin ID

C227;

UMLS CUI

C0002333;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ALPRAZolam [LOINC component]
- Alprazolam [ICD-11 Extension code]
- Alprazolam (substance) [SNOMED CT concept]
- Product containing alprazolam (medicinal product) [SNOMED CT concept]
- alprazolam [ATC Code]
- alprazolam [Substance BNPC]
- alprazolam [MeSH concept]
- alprazolam [MeSH Descriptor]
- alprazolam [SNOMED Notion]
Validated automatic mappings to BTNT
- alprazolam [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
- Cytochrome P450 3A5 [NCIt concept]
- Cytochrome P450 3A7 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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