Felodipine - CISMeF

Preferred Label : Felodipine;

NCIt definition : A dihydropyridine calcium channel blocking agent. Felodipine inhibits the influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04);

UNII : OL961R6O2C;

CAS number : 72509-76-3;

Drug name : Plendil;

Chemical formula : C18H19Cl2NO4;

ChEBI ID : CHEBI:585948;

Codes from synonyms : 01010;

Details

Origin ID

C29046;

UMLS CUI

C0015772;

Automatic exact mappings (from CISMeF team)
- plendil [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Felodipine [ICD-11 Extension code]
- Felodipine (substance) [SNOMED CT concept]
- Product containing felodipine (medicinal product) [SNOMED CT concept]
- felodipine [ATC Code]
- felodipine [Substance BNPC]
- felodipine [MeSH concept]
- felodipine [MeSH Descriptor]
Validated automatic mappings to BTNT
- felodipine [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
- Cytochrome P450 3A5 [NCIt concept]
- Cytochrome P450 3A7 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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