Preferred Label : Cyclosporine;

NCIt synonyms : CsA; Cyclosporin; Ciclosporin; Cyclosporine Modified; CyA;

NCIt related terms : Cyclosporin A; 27-400;

NCIt definition : A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release. (NCI04);

Alternative definition : NCI-GLOSS: A drug used to help reduce the risk of rejection of organ and bone marrow transplants by the body. It is also used in clinical trials to make cancer cells more sensitive to anticancer drugs.;

UNII : 83HN0GTJ6D;

InChIKey : PMATZTZNYRCHOR-CGLBZJNRSA-N;

CAS number : 59865-13-3;

Drug name : Neoral; SangCya; Sandimmune; Gengraf;

Molecule name : OL 27-400; 27-400;

Chemical formula : C62H111N11O12;

NSC code : 290193;

ChEBI ID : CHEBI:4031;

Codes from synonyms : NSC0290193; CDR0000045187; 00088; 45569;

Details


Keyword's position in hierarchy(ies) : arborescence

Main resources

You can consult :


https://www.rheuma-net.ch/fr/doc/ciclosporine/viewdocument/349
2023
Switzerland
guideline
Cyclosporine
cyclosporine
cyclosporine
Background Treatment

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04/05/2025


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