" /> Vincristine - CISMeF





Preferred Label : Vincristine;

NCIt synonyms : Vincrystine; Leurocristine; 22-Oxovincaleukoblastine; VCR; LCR;

NCIt definition : A natural alkaloid isolated from the plant Vinca rosea Linn. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04);

Alternative definition : NCI-GLOSS: The active ingredient in a drug used to treat acute leukemia. It is used in combination with other drugs to treat Hodgkin disease, non-Hodgkin lymphoma, rhabdomyosarcoma, neuroblastoma, and Wilms tumor. Vincristine is also being studied in the treatment of other types of cancer. It blocks cell growth by stopping cell division. It is a type of vinca alkaloid and a type of antimitotic agent.;

UNII : 5J49Q6B70F;

InChIKey : OGWKCGZFUXNPDA-CFWMRBGOSA-N;

CAS number : 57-22-7;

Chemical formula : C46H56N4O10;

ChEBI ID : CHEBI:28445;

Codes from synonyms : NSC0067574; CDR0000045435; 02166; 536;

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29/05/2025


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