Preferred Label : Methadone Hydrochloride;
NCIt synonyms : Methadone;
NCIt related terms : Althose;
NCIt definition : The hydrochloride salt of methadone, a synthetic opioid with analgesic activity. Similar
to morphine and other morphine-like agents, methadone mimics the actions of endogenous
peptides at CNS opioid receptors, primarily the mu-receptor, resulting in characteristic
morphine-like effects including analgesia, euphoria, sedation, respiratory depression,
miosis, bradycardia and physical dependence. Because of the prolonged half-life of
methadone compared to other morphine-like agents such as heroin, the onset of opiate
withdrawal symptoms is slower, the duration of opiate withdrawal is prolonged, and
opiate withdrawal symptoms are less severe.;
Alternative definition : NCI-GLOSS: A drug used to treat moderate to severe pain that does not respond to other
types of pain medicine. It is also used to help people who are addicted to opioid
drugs such as heroin. Methadone hydrochloride binds to opioid receptors in the central
nervous system. It is a type of analgesic agent and a type of opioid.;
UNII : 229809935B;
InChIKey : FJQXCDYVZAHXNS-UHFFFAOYSA-N;
CAS number : 1095-90-5;
Drug name : Adanon; Dolophine; Methadose; Althose;
Chemical formula : C21H27NO.HCl;
NSC code : 19600;
ChEBI ID : CHEBI:50140;
Codes from synonyms : NSC0019600; CDR0000454762;
Origin ID : C638;
UMLS CUI : C0721688;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- Validated automatic mappings to NTBT
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
