Cytochrome P450 2B6

Preferred Label : Cytochrome P450 2B6;

NCIt synonyms : CYP2B6; P450; P450 IIB1; Cytochrome P450 Family 2 Subfamily B Polypeptide 6; CYPIIB6; CPB6; IIB1; Cytochrome P450 CYP2B6; CYP2B; Cytochrome P450 IIB1; EC 1.14.14.1; Cytochrome P450-2B6;

NCIt definition : Cytochrome P450 2B6 (491 aa, 56 kDa) is encoded by the human CYP2B6 gene. This protein plays a role in the metabolism of steroids and pharmaceuticals.;

NCIt note : Cytochrome P450 2B6 oxidizes xenobiotics such as cyclophosphamide and ifosfamide.;

Details

Origin ID

C40050;

UMLS CUI

C0534137;

Currated CISMeF NLP mapping
- Cytochrome P-450 CYP2B6 [MeSH Descriptor]
- Cytochrome P-450 CYP2B6 [MeSH concept]
OMIM relation
- Cytochrome p450, subfamily iib, polypeptide 6 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CYP2B6 protein, human [MeSH Supplementary Concept]
- CYP2B6 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
enzyme_metabolizes_chemical_or_drug
- Bupropion [NCIt concept]
- Bupropion Hydrobromide [NCIt concept]
- Bupropion Hydrochloride [NCIt concept]
- Bupropion Hydrochloride Controlled-release [NCIt concept]
- Cyclophosphamide [NCIt concept]
- Efavirenz [NCIt concept]
- Ifosfamide [NCIt concept]
- Methadone [NCIt concept]
- Methadone Hydrochloride [NCIt concept]
gene_encodes_gene_product
- CYP2B6 Gene [NCIt concept]
- Cytochrome P450 Family Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_chemical_classification
- Heme Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Arachidonic Acid Metabolism Pathway [NCIt concept]
- Drug Metabolism by Cytochrome P450 Pathway [NCIt concept]
- Lipid Metabolism and Toxicity Pathway [NCIt concept]
- Metabolism of Xenobiotics by Cytochrome P450 Pathway [NCIt concept]
- Retinol Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Detoxification [NCIt concept]
- Hydroxylation [NCIt concept]
- Intermediary Metabolic Process [NCIt concept]
- Metabolic Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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