Preferred Label : methadone;

MeSH definition : A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3);

CISMeF synonym : GlaxoSmithKline brand of methadone hydrochloride; addiCare brand of methadone hydrochloride; biomet brand of methadone hydrochloride; esteve brand of methadone hydrochloride; generics brand of methadone hydrochloride; mallinckrodt brand of methadone hydrochloride; martindale brand of methadone hydrochloride; pharmascience brand of methadone hydrochloride; pinewood brand of methadone hydrochloride; rosemont brand of methadone hydrochloride; roxane brand of methadone hydrochloride; yamanouchi brand of methadone hydrochloride;

MeSH hyponym : methaddict; methadone hydrochloride; dolophine; pinadone; amidone; phenadone; symoron; physeptone; metadol; methadose; metasedin; biodone; methex; Hydrochloride, Methadone; Phymet;

MeSH CAS label : 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-;

MeSH Related Number : methadone hydrochloride; 1095-90-5 (HCl); 76-99-3 (Methadone); 229809935B;

Registry Number MeSH : 76-99-3;

Related CAS MeSH : 229809935B (Methadone hydrochloride);

MeSH annotation : for methadone maintenance treatment, coordinate with OPIATE SUBSTITUTION TREATMENT;

Wikipedia link : https://en.wikipedia.org/wiki/Methadone;

Codes EINECS : 200-996-9;

Is substance : O;

UNII : UC6VBE7V1Z;

InChIKey : USSIQXCVUWKGNF-UHFFFAOYSA-N;

Details


Main resources

You can consult :

A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)

https://ansm.sante.fr/actualites/deces-denfants-suite-a-lingestion-accidentelle-de-methadone-rappel-des-regles-de-bon-usage
2021
false
false
false
France
French
pharmacovigilance note
guidelines for drug use
methadone
child
Accidental ingestion of drug
accident prevention
adolescent
accidents, home
poisoning
death

---
https://ansm.sante.fr/tableau-marr/methadone
2021
false
false
false
France
French
risk management
methadone
administration, oral
patient education handout
accidents, home
patients guideline
drug information
child
Accidental ingestion of drug
Accidental poisoning caused by methadone (disorder)

---
https://www.ansm.sante.fr/actualites/lansm-rappelle-les-risques-de-la-methadone-et-limportance-de-disposer-de-la-naloxone
2020
false
false
false
France
French
methadone
antidotes
naloxone
opioid-related disorders
pharmacovigilance note
Poisoning caused by methadone (disorder)

---
https://www.has-sante.fr/jcms/p_3113581/fr/zoryon
2020
false
false
false
France
French
evaluation of the transparency committee
treatment outcome
methadone hydrochloride
methadone hydrochloride
administration, oral
insurance, health, reimbursement
adult
adolescent
Cancer Pain
analgesics, opioid
analgesics, opioid
diphenylpropylamine derivatives
methadone
methadone

---
https://www.cfp.ca/content/66/11/e273
2020
Canada
journal article
changing
methadone
british columbia
methadone
pigeon, nos

---
http://www.theses.fr/2019CLFAS023
2019
France
dissertations, academic
patients
opiate agonist, nos
pain
pain measurement
addiction, nos
opioids
pain, nos
analgesics, opioid
methadone
methadone
Dependency, Psychological
buprenorphine
buprenorphine
has patient
behavior, addictive
pain

---
Health Canada recommends that children and youth not use cough and cold products that contain opioids
http://canadiensensante.gc.ca/recall-alert-rappel-avis/hc-sc/2019/69080a-fra.php
2019
false
false
false
Canada
French
English
child
adolescent
antitussive agents
codeine
hydrocodone
cough
common cold
normethadone
opioid-related disorders
opium alkaloids and derivatives
risk
pharmacovigilance note
methadone
methadone

---
http://www.sudoc.fr/232948887
2018
France
dissertations, academic
methadone
postman
methadone
death
concentration
Adenoma
data collection
attention

---
http://www.cfp.ca/content/63/3/e153.full
2017
false
false
true
false
Canada
French
journal article
opioid-related disorders
methadone
analgesics, opioid
Buprenorphine, Naloxone Drug Combination
pregnancy
adolescent
aged
case reports

---
http://www.has-sante.fr/portail/jcms/c_2748736/fr/chlorhydrate-de-methadone-ap-hp-methadone-ap-hp
2017
false
false
false
France
French
evaluation of the transparency committee
insurance, health, reimbursement
administration, oral
methadone
methadone
methadone hydrochloride

---
http://www.cochrane.org/fr/CD012499/la-methadone-pour-la-douleur-neuropathique-chez-ladulte
2017
false
false
false
France
United Kingdom
French
french abstract
neuralgia
methadone
Neuropathic Pain
adult
treatment outcome
Evidence-Based medicine
analgesics, opioid
review of literature

---
https://rmlg.uliege.be/article/2418
2015
false
true
false
Belgium
French
journal article
opioid-related disorders
substance withdrawal syndrome
substance withdrawal syndrome
heroin dependence
methadone
heroin
Opioid withdrawal
anesthesia

---
https://centres-antipoison.net/wp-content/uploads/2017/08/CCTV_Methadone_Pediatrie_6_Ans_Valide.pdf
2015
false
false
false
false
France
French
scientific and technical information
child
administration, oral
risk factors
Accidental drug intake by child
environmental exposure
Accidental poisoning caused by methadone (disorder)
france
accidents, home
risk management
capsules
methadone
pharmaceutical solutions
poisoning by methadone

---
https://primary-hospital-care.ch/fr/article/doi/phc-f.2014.00461/
2014
false
false
false
Switzerland
French
journal article
heroin dependence
heroin dependence
heroin dependence
methadone
physician-patient relations
narcotics
opiate substitution treatment
physicians

---
https://www.ofdt.fr/BDD/publications/docs/eftxabua.pdf
https://www.ofdt.fr/publications/collections/tendances/les-traitements-de-substitution-aux-opiaces-donnees-recentes-tendances-94-octobre-2014/
2014
false
false
false
France
French
opiate substitution treatment
france
journal article
opiate substitution treatment
buprenorphine
methadone
narcotics

---
http://www.meddispar.fr/Questions-Reponses/Quelles-sont-les-modalites-de-transport-de-la-methadone-sous-la-forme-gelule
2014
false
false
false
France
French
drug information
methadone
carrying
capsules
lifting
methadone
with shape
formed

---
http://www.cochrane.org/fr/CD002207
2014
false
true
false
United Kingdom
France
treatment outcome
review of literature
french abstract
buprenorphine
methadone
opioid-related disorders
placebos

---
http://www.prescrire.org/Fr/3/31/47730/0/2012/ArchiveNewsDetails.aspx
2013
methadone
capsules

---
http://www.lecrat.eu/?s=M%C3%A9thadone
2013
France
French
infant, newborn
methadone
pregnancy
narcotics
methadone
opiate substitution treatment
drug information

---
http://www.cochrane.org/fr/CD008939
2013
United Kingdom
France
French
Cardiotoxicity
review of literature
opioid-related disorders
methadone
treatment outcome
narcotics
long qt syndrome
electrocardiography
risk assessment
french abstract

---
http://www.has-sante.fr/portail/upload/docs/application/pdf/2012-04/chlorhydrate_de_methadone_29022012_avis_ct11413.pdf
http://www.has-sante.fr/portail/jcms/c_623558/methadone-ap-hp
http://www.has-sante.fr/portail/jcms/c_490355/chlorhydrate-de-methadone
http://www.has-sante.fr/portail/jcms/c_399152/chlorhydrate-de-methadone-assistance-publique-hopitaux-de-paris-40-mg/15-ml-sirop-en-recipient-unidoseboites-de-1chlorhydrate-de-methadone-assistance-publique-hopitaux-de-paris-60-mg/15-ml-sirop-en-recipient-unidoseboites-de-1
http://www.has-sante.fr/portail/jcms/c_1231602/methadone
2012
France
French
evaluation of the transparency committee
methadone
administration, oral
methadone
methadone hydrochloride
opiate substitution treatment
opioid-related disorders
narcotics
insurance, health, reimbursement
treatment outcome

---
http://www.cochrane.org/fr/CD008025
2012
United Kingdom
France
French
methadone
adult
chronic pain
treatment outcome
analgesics, opioid
narcotics
review of literature
french abstract

---
https://centres-antipoison.net/wp-content/uploads/2017/08/Rapport_CCTV_Methadone_Pediatrie_VF_Octobre_2012.pdf
2012
France
French
methadone
child
scientific and technical information
infant
capsules
pharmaceutical solutions

---
https://medias.vie-publique.fr/data_storage_s3/rapport/pdf/024000177.pdf
France
French
france
methadone
substance-related disorders
methadone
methadone
methadone
methadone
practice guidelines as topic
drug prescriptions
substance abuse treatment centers
ambulatory care
prisons
buprenorphine
buprenorphine
opiate substitution treatment
technical report

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=68726979
2012
France
summary of product characteristics
package leaflet
capsules
methadone

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=65738008
2012
France
summary of product characteristics
package leaflet
methadone
capsules

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=63009443
2012
France
summary of product characteristics
package leaflet
methadone
capsules

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=60998856
2012
France
summary of product characteristics
package leaflet
capsules
methadone

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=67255773
2012
France
summary of product characteristics
package leaflet
pharmaceutical solutions
methadone
adaptor protein complex 1
AP protocol 1

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=67296909
2012
France
summary of product characteristics
package leaflet
AP protocol 1
capsules
adaptor protein complex 1
methadone

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=61144346
2012
France
summary of product characteristics
package leaflet
hospitals
publications
paris
pharmaceutical solutions
methadone
methadone hydrochloride

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=61687452
2012
France
summary of product characteristics
package leaflet
hospitals
methadone hydrochloride
publications
methadone
paris
pharmaceutical solutions

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=68874401
2012
France
summary of product characteristics
package leaflet
methadone
pharmaceutical solutions
paris
publications
hospitals
methadone hydrochloride

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=61610484
2012
France
summary of product characteristics
package leaflet
publications
hospitals
methadone hydrochloride
paris
pharmaceutical solutions
methadone

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=63644827
2012
France
summary of product characteristics
package leaflet
hospitals
paris
methadone
methadone hydrochloride
pharmaceutical solutions
publications

---
http://drogues-sante-societe.ca/les-effets-indesirables-des-medicaments-de-substitution-dans-le-traitement-de-la-dependance-aux-opioides/
http://droguess.whc.ca/wp-content/uploads/2012/10/vol10_no1_2.pdf
2011
Canada
French
journal article
methadone
buprenorphine
analgesics, opioid
opioid-related disorders
opiate substitution treatment

---
https://centres-antipoison.net/wp-content/uploads/2017/08/Rapport_CCTV_Methadone_a_2_ans_2010.pdf
2010
France
French
technical report
drug information
methadone
adult
child
narcotics
france
pharmaceutical solutions
capsules
suicide, attempted
administration, oral
product surveillance, postmarketing

---
https://www.ofdt.fr/BDD/publications/docs/eftxtcp5.pdf
2009
false
France
French
methadone
buprenorphine
narcotics
substance-related disorders
opiate substitution treatment
scientific and technical information

---
https://www.jle.com/fr/revues/medecine/med/e-docs/00/04/48/DD/resume.phtml
2009
France
French
methadone
narcotics
analgesics, opioid
opiate substitution treatment
journal article

---
https://pgtmsite.files.wordpress.com/2024/01/methadone_es_20090226.pdf
2009
Canada
drug information
pain management
Methadone Measurement
Pain Therapy
Methadone
methadone
pain
methadone

---
http://www.cochrane.org/fr/CD002209
2009
false
true
false
United Kingdom
France
opioid-related disorders
review of literature
french abstract
opioid-related disorders
methadone

---
http://www.cochrane.org/fr/CD003409
2009
false
true
false
United Kingdom
France
methadone
opioid-related disorders
treatment outcome
Opioid withdrawal
review of literature
french abstract
methadone

---
https://centres-antipoison.net/wp-content/uploads/2017/08/Rapport_CCTV_Methadone_a_1_an.pdf
2009
France
scientific and technical information
methadone
capsules
marketing
pharmaceutical solutions
report

---
http://www.cochrane.org/fr/CD002208
2008
false
true
false
United Kingdom
France
methadone
treatment outcome
review of literature
french abstract
methadone
opioid-related disorders

---
http://www.cochrane.org/fr/CD002210
2008
false
true
false
false
United Kingdom
France
methadone
treatment outcome
review of literature
french abstract
methadyl acetate
heroin dependence

---
https://www.revmed.ch/RMS/2008/RMS-175/Quelle-evolution-pour-un-patient-substitue-a-la-methadone-au-long-cours-1
2008
Switzerland
journal article
methadone
patients

---
http://www.erudit.org/revue/dss/2008/v7/n2/037565ar.html
2008
Canada
journal article
syringes
methadone
ethical issues
ethics

---
http://www.meddispar.fr/medicaments/3791462
2008
France
French
capsules
administration, oral
narcotics
drug monitoring
continuity of patient care
methadone
drug prescriptions
legislation, drug
methadone
drug information

---
http://www.meddispar.fr/medicaments/3791485
2008
France
French
administration, oral
capsules
narcotics
drug prescriptions
legislation, drug
methadone
drug monitoring
continuity of patient care
methadone
drug information

---
http://www.meddispar.fr/medicaments/3389435
2008
France
French
methadone
pharmaceutical solutions
administration, oral
narcotics
drug prescriptions
legislation, drug
methadone
drug information

---
http://www.meddispar.fr/medicaments/3791491
2008
France
French
methadone
capsules
administration, oral
narcotics
drug prescriptions
legislation, drug
drug monitoring
continuity of patient care
methadone
drug information

---
https://bdoc.ofdt.fr/index.php?lvl=notice_display&id=52818
2008
false
false
false
technical report
hospitals
methadone
prisons

---
http://www.meddispar.fr/medicaments/3805081
2008
France
French
continuity of patient care
drug prescriptions
legislation, drug
narcotics
capsules
methadone
administration, oral
drug monitoring
methadone
drug information

---
http://www.meddispar.fr/medicaments/3400421
2008
France
French
methadone
pharmaceutical solutions
administration, oral
drug monitoring
continuity of patient care
drug prescriptions
legislation, drug
narcotics
methadone
drug information

---
http://www.meddispar.fr/medicaments/3389458
2008
France
French
methadone
pharmaceutical solutions
administration, oral
narcotics
continuity of patient care
drug monitoring
drug prescriptions
legislation, drug
methadone
drug information

---
http://www.meddispar.fr/medicaments/3791479
2008
France
French
methadone
capsules
administration, oral
narcotics
drug monitoring
continuity of patient care
drug prescriptions
legislation, drug
methadone
drug information

---
http://www.meddispar.fr/medicaments/3400415
2008
France
French
methadone
pharmaceutical solutions
administration, oral
narcotics
drug monitoring
continuity of patient care
drug prescriptions
legislation, drug
methadone
drug information

---
http://www.meddispar.fr/medicaments/3389441
2008
France
French
methadone
pharmaceutical solutions
administration, oral
narcotics
drug prescriptions
legislation, drug
methadone
drug information

---
http://www.health.belgium.be/sites/default/files/uploads/fields/fpshealth_theme_file/9184410/Avis%20relatif%20aux%20traitements%20de%20substitution%20chez%20les%20usagers%20de%20drogues%20de%20type%20opiac%C3%A9%20%28octobre%202006%29%20%28CSH%208178%29.pdf
2006
true
Belgium
French
methadone
narcotics
buprenorphine
opioid-related disorders
methadone
narcotics
buprenorphine
buprenorphine
methadone
opiate substitution treatment
guidelines for drug use

---
https://www.inrs.fr/media.html?refINRS=TC%20111
2006
France
French
work
opioid-related disorders
heroin dependence
buprenorphine
methadone
arousal
automobile driving
mass screening
heroin dependence
disabled persons
opiate substitution treatment
journal article

---
http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=35889
2006
France
French
buprenorphine
narcotics
acute disease
methadone
scientific and technical information

---
https://www.ofdt.fr/BDD/publications/docs/epfxpblc.pdf
https://medias.vie-publique.fr/data_storage_s3/rapport/pdf/064000007.pdf
https://www.ofdt.fr/publications/collections/rapports/rapports-d-etudes/2005/phenomenes-emergents-lies-aux-drogues-en-2004-sixieme-rapport-national-du-dispositif-trend-decembre-2005/
2005
false
France
French
cocaine
cocaine
cocaine
N-Methyl-3,4-methylenedioxyamphetamine
N-Methyl-3,4-methylenedioxyamphetamine
N-Methyl-3,4-methylenedioxyamphetamine
amphetamines
amphetamines
amphetamines
hallucinogens
mushroom poisoning
ketamine
ketamine
ketamine
lysergic acid diethylamide
lysergic acid diethylamide
lysergic acid diethylamide
cannabis
cannabis
cannabis
marijuana abuse
marijuana abuse
psychotropic drugs
flunitrazepam
flunitrazepam
flunitrazepam
trihexyphenidyl
trihexyphenidyl
trihexyphenidyl
crack cocaine
crack cocaine
crack cocaine
clonazepam
clonazepam
clonazepam
diazepam
diazepam
diazepam
substance-related disorders
substance-related disorders
substance-related disorders
substance-related disorders
opioid-related disorders
opioid-related disorders
amphetamine-related disorders
amphetamine-related disorders
cocaine-related disorders
cocaine-related disorders
france
age distribution
sex distribution
health surveys
socioeconomic factors
adolescent
adult
urban population
population characteristics
heroin
heroin
heroin
buprenorphine
buprenorphine
buprenorphine
methadone
methadone
methadone
morphine
morphine
morphine
codeine
codeine
codeine
technical report
dictionaries, medical
table
public health evaluation

---
http://www.has-sante.fr/portail/display.jsp?id=c_272329
2004
France
French
practice guideline
table
opioid-related disorders
buprenorphine
methadone
buprenorphine
methadone
drug utilization
opioid-related disorders
physician-patient relations
drug utilization review
socioeconomic factors
opioid-related disorders
office visits
patient care
dose-response relationship, drug
interprofessional relations
continuity of patient care
emergency treatment
drug prescriptions
communication
substance-related disorders
opiate substitution treatment

---
http://www.has-sante.fr/portail/display.jsp?id=c_272358
2004
France
French
behavior, addictive
france
Cost-Benefit analysis
treatment outcome
methadone
buprenorphine
buprenorphine
methadone
poverty
professional practice
education, continuing
biomedical research
biomedical research
behavior, addictive
opioid-related disorders
opioid-related disorders
methadone
methadone
methadone
buprenorphine
buprenorphine
buprenorphine
continuity of patient care
community networks
substance withdrawal syndrome
dose-response relationship, drug
drug prescriptions
substance abuse, intravenous
pregnancy
prisons
quality of health care
Contraindications, Procedure
opiate substitution treatment
consensus
dictionaries, medical
Contraindications, Drug

---
https://www.ofdt.fr/BDD/publications/docs/epfxack6.pdf
2004
false
France
French
general practice
methadone
methadone
methadone
buprenorphine
age distribution
sex distribution
general practitioners
opioid-related disorders
drug prescriptions
opiate substitution treatment
monograph

---
https://www.ofdt.fr/BDD/publications/docs/epfxclj7.pdf
2003
false
France
French
opioid-related disorders
pregnant women
pregnancy
methadone
methadone
methadone
buprenorphine
buprenorphine
buprenorphine
pregnancy complications
poverty
socioeconomic factors
pregnancy, multiple
neonatal abstinence syndrome
continuity of patient care
infant, newborn
mother-child relations
behavior, addictive
infant, newborn, diseases
pregnancy, high-risk
opiate substitution treatment
monograph
bibliography
figure
health surveys

---
https://www.ofdt.fr/BDD/publications/docs/epfxofj6.pdf
2003
false
France
French
general practice
methadone
opioid-related disorders
methadone
methadone
buprenorphine
methadone
buprenorphine
buprenorphine
buprenorphine
substance abuse treatment centers
general practitioners
community networks
hepatitis C
hiv infections
drug overdose
crime
prisons
morphine
codeine
drug approval
drug prescriptions
treatment outcome
opiate substitution treatment
technical report
bibliography

---
https://medias.vie-publique.fr/data_storage_s3/rapport/pdf/034000486.pdf
2003
false
France
French
france
substance-related disorders
age distribution
substance-related disorders
central nervous system stimulants
narcotics
hallucinogens
psychotropic drugs
health surveys
data collection
population characteristics
sex distribution
opioid-related disorders
injections
hiv infections
substance-related disorders
acquired immunodeficiency syndrome
hepatitis C
hepatitis B
injections
opioid-related disorders
heroin
opioid-related disorders
buprenorphine
buprenorphine
heroin dependence
amphetamine-related disorders
buprenorphine
buprenorphine
heroin
methadone
methadone
morphine
morphine
codeine
codeine
N-Methyl-3,4-methylenedioxyamphetamine
amphetamine
amphetamine-related disorders
cocaine-related disorders
crack cocaine
cocaine
cocaine-related disorders
cocaine
N-Methyl-3,4-methylenedioxyamphetamine
socioeconomic factors
hallucinogens
N-Methyl-3,4-methylenedioxyamphetamine
N-Methyl-3,4-methylenedioxyamphetamine
hallucinogens
hallucinogens
methamphetamine
methamphetamine
amphetamine
methamphetamine
amphetamine
central nervous system stimulants
central nervous system stimulants
lysergic acid diethylamide
lysergic acid diethylamide
lysergic acid diethylamide
ketamine
urban population
ketamine
ketamine
adult
flunitrazepam
psychotropic drugs
paris
trihexyphenidyl
Sex Work
alcoholism
marijuana smoking
substance-related disorders
sex workers
technical report

---
https://www.santepubliquefrance.fr/recherche/#search=Etude+de+la+"méthadone+relais"+dans+le+département+des+Bouches-du-Rhône
2001
France
French
france
methadone
substance-related disorders
narcotics
drug prescriptions
methadone
opiate substitution treatment
journal article

---
http://www.health.belgium.be/sites/default/files/uploads/fields/fpshealth_theme_file/4404389/Rapport%20de%20suivi%20de%20la%20conf%C3%A9rence%20de%20consensus%20sur%20la%20m%C3%A9thadone%20%28novembre%202000%29%20%28CSH%206931%29.pdf
2000
true
Belgium
French
general practitioners
methadone
methadone
substance-related disorders
Evidence-Based medicine
belgium
general practice
consensus development conferences as topic
drug prescriptions
patient dropouts
technical report
consensus

---
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04/05/2024


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