Preferred Label : naloxone;

MeSH definition : A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.;

CISMeF synonym : SERB brand of naloxone hydrochloride; curamed brand of naloxone hydrochloride; naloxonratiopharm; ratiopharm brand of naloxone hydrochloride; united drug brand of naloxone hydrochloride; lamepro brand of naloxone hydrochloride; Bristol-Myers squibb brand of naloxone hydrochloride; bristol myers squibb brand of naloxone hydrochloride; endo brand of naloxone hydrochloride; boots brand of naloxone hydrochloride; abello brand of naloxone hydrochloride;

MeSH hyponym : naloxone hydrochloride, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer; Naloxone Hydrochloride Dihydride; Naloxone Hydrochloride; naloxone abello; naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer; narcan; naloxon-ratiopharm; naloxone hydrobromide; naloxon curamed; MRZ-2593; nalone; Curamed, Naloxon; Naloxon Ratiopharm; Abello, Naloxone; Hydrochloride, Naloxone; Dihydride, Naloxone Hydrochloride; Hydrochloride Dihydride, Naloxone; Narcanti; MRZ 2593; MRZ2593; MRZ 2593-Br; MRZ 2593 Br; MRZ 2593Br; Hydrobromide, Naloxone;

MeSH CAS label : Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-;

MeSH Related Number : naloxone hydrobromide; naloxone hydrochloride; naloxone hydrochloride dihydride; naloxone hydrochloride, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer; naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer; 357-08-4 (Naloxone hydrochloride); 465-65-6 (Naloxone); 30299-78-6; 51481-60-8; 65700-73-4; 69133-14-8; F850569PQR;

Registry Number MeSH : 465-65-6;

Related CAS MeSH : 30299-78-6 (Naloxone hydrobromide); 51481-60-8 (Naloxone hydrochloride dihydride); 69133-14-8 (Naloxone hydrochloride, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer); 65700-73-4 (Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer); F850569PQR (Naloxone hydrochloride);

Wikipedia link : https://en.wikipedia.org/wiki/Naloxone;

Codes EINECS : 207-365-7;

Is substance : O;

UNII : 36B82AMQ7N;

InChIKey : UZHSEJADLWPNLE-GRGSLBFTSA-N;

Details


Main resources

You can consult :

A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.

https://www.has-sante.fr/jcms/p_3505841/fr/ventizolve-naloxone-antidote-des-surdoses-aux-opioides
2024
false
false
false
France
administration, intranasal
treatment outcome
insurance, health, reimbursement
Naloxone Hydrochloride Dihydride
narcotic antagonists
emergency treatment
adult
naloxone
evaluation of the transparency committee
Opiate Overdose
naloxone
antidotes

---
https://ansm.sante.fr/tableau-marr/naloxone-3
2023
false
false
false
France
French
risk management
video recording
guidelines for drug use
patients guideline
naloxone
naloxone
administration, intranasal

---
https://www.cmaj.ca/content/195/38/E1312
2023
France
journal article
guideline
canada
orientation, nos
Catenin Delta-1
Breast Cancer Anti-Estrogen Resistance Protein 1
with distribution
snacks
paper
naloxone
Distribution
Coronavirus Anxiety Scale
CDISC SEND Distribution Terminology
BCAR1 wt Allele
Pharmacokinetics: Distribution
Packaging Case
Distribution
naloxone
marketing
drug overdose, nos
Naloxone
Handout
Case Dosing Unit
True Case Status
Use
CTNND1 wt Allele
No Cases Transmission Pattern
orientation
Case

---
https://www.ansm.sante.fr/actualites/surdosage-et-overdose-dopioides-point-sur-loffre-therapeutique-de-la-naloxone-en-france
2023
false
false
false
France
French
Overdose of opiate (disorder)
emergency treatment
drug information
opiate alkaloids
poisoning
naloxone
naloxone

---
https://ansm.sante.fr/tableau-marr/naloxone-2
2022
false
false
false
France
French
guidelines for drug use
risk management
naloxone
naloxone
injections, intramuscular
patient education handout
patients guideline
naloxone
emergency treatment
Opiate Overdose
narcotic antagonists
antidotes

---
https://publications.msss.gouv.qc.ca/msss/document-002355/
2022
Canada
scientific and technical information
policeman
police
Administration
administration, intranasal
drug overdose, nos
opiate agonist, nos
Opiate Overdose
nasal route
naloxone
naloxone
omasum

---
http://publications.msss.gouv.qc.ca/msss/document-002079/
2022
false
false
false
false
Canada
first aid
Overdose of opiate (disorder)
popular works
naloxone
naloxone
Injection moulding
drug overdose, nos
injection, nos
administration
prescription drug misuse
Administration
drug overdose
opiate agonist, nos
opioids
injections

---
https://www.health.belgium.be/fr/avis-9695-mise-disposition-de-naloxone-aux-consommateurs-dopioides
2022
Belgium
public health guidelines
naloxone
opioids
Set, Psychology
analgesics, opioid
economics
naloxone
opiate agonist, nos
judgment
devices
device, nos

---
https://www.has-sante.fr/jcms/p_3352223/fr/oxypronal-lp-oxycodone/naloxone-douleur-severe
2022
false
false
false
France
drug combinations
naloxone
oxycodone
drugs, generic
treatment outcome
insurance, health, reimbursement
administration, oral
Delayed-Action preparations
narcotic antagonists
analgesics, opioid
evaluation of the transparency committee
severe pain
pain

---
http://publications.msss.gouv.qc.ca/msss/document-002081/
2022
false
false
false
false
Canada
Overdose of opiate (disorder)
first aid
popular works
drug overdose, nos
administration
prescription drug misuse
drug overdose
naloxone
naloxone
nose, nos
administration, intranasal
route of administration, nos

---
https://ansm.sante.fr/tableau-marr/naloxone-1
2021
false
false
false
France
French
naloxone
guidelines for drug use
patients guideline
administration, intranasal
nasal sprays
narcotic antagonists
naloxone
morphine derivatives
Overdose of opiate (disorder)
naloxone
narcotic antagonists

---
https://solidarites-sante.gouv.fr/prevention-en-sante/addictions/article/surdoses-overdose-d-opioides-la-naloxone-est-utilisable-par-tous-et-peut-sauver
2020
false
false
false
France
opiate alkaloids
analgesics, opioid
poisoning
antidotes
Overdose of opiate (disorder)
scientific and technical information
popular works
naloxone

---
https://www.cfp.ca/content/66/12/e302
2020
Canada
journal article
buprenorphine
naloxone
tool, nos
receptors, opioid, mu
naloxone
opiate agonist, nos
buprenorphine
receptors, opioid
receptors, opioid

---
https://www.ansm.sante.fr/actualites/lansm-rappelle-les-risques-de-la-methadone-et-limportance-de-disposer-de-la-naloxone
2020
false
false
false
France
French
methadone
antidotes
naloxone
opioid-related disorders
pharmacovigilance note
Poisoning caused by methadone (disorder)

---
https://solidarites-sante.gouv.fr/IMG/pdf/covid-naloxone-annexe-fichememopros.pdf
2020
false
false
false
France
coronavirus infections
pneumonia, viral
Overdose of opiate (disorder)
emergency treatment
opiate alkaloids
narcotic antagonists
scientific and technical information
antidotes
naloxone
prescription drug misuse
pandemics
COVID-19

---
https://solidarites-sante.gouv.fr/IMG/pdf/covid-fiche_naloxone_.pdf
2020
false
false
false
France
coronavirus infections
pneumonia, viral
naloxone
opiate alkaloids
emergency treatment
antidotes
narcotic antagonists
Overdose of opiate (disorder)
scientific and technical information
naloxone
prescription drug misuse
pandemics
COVID-19

---
https://solidarites-sante.gouv.fr/IMG/pdf/covid_naloxone-annexe-fichememousagers.pdf
2020
France
coronavirus infections
pneumonia, viral
popular works
drug overdose, nos
coronavirus
prescription drug misuse
antidotes
opioids
life
naloxone
drug overdose
Employment
opiate agonist, nos
antidote, nos
attention
unemployment
analgesics, opioid
coronavirus, nos
attention, nos
naloxone
employment
prescription drug misuse
pandemics
COVID-19

---
https://www.has-sante.fr/jcms/p_3159924/fr/nyxoid
2020
false
false
false
France
naloxone
naloxone
narcotic antagonists
insurance, health, reimbursement
treatment outcome
emergency treatment
Overdose of opiate (disorder)
prescription drug misuse
opiate alkaloids
administration, intranasal
evaluation of the transparency committee

---
https://www.has-sante.fr/jcms/pprd_2982959/fr/prenoxad-naloxone-antidote
2019
false
false
false
France
naloxone
guidelines for drug use
emergency treatment
Overdose of opiate (disorder)
treatment outcome
insurance, health, reimbursement
adult
opiate alkaloids
poisoning
evaluation of the transparency committee
naloxone
antidotes

---
https://www.has-sante.fr/portail/jcms/c_2891870/fr/prenoxad
2019
false
false
false
France
French
evaluation of the transparency committee
treatment outcome
insurance, health, reimbursement
adult
emergency treatment
Naloxone Hydrochloride
narcotic antagonists
naloxone
opioids
drug overdose
injections
naloxone
analgesics, opioid

---
https://www.has-sante.fr/portail/jcms/c_2853739/fr/oxsynia
2018
false
false
false
false
France
French
evaluation of the transparency committee
treatment outcome
administration, oral
Delayed-Action preparations
drug combinations
Oxycodone Hydrochloride
Oxycodone Hydrochloride
oxycodone and naloxone
analgesics, opioid
analgesics, opioid
Naloxone Hydrochloride Dihydride
Naloxone Hydrochloride Dihydride
narcotic antagonists
narcotic antagonists
insurance, health, reimbursement
adult
pain
restless legs syndrome
narcotics
Cancer Pain
osteoarthritis, knee
osteoarthritis, hip
low back pain
chronic disease
oxycodone naloxone combination
oxycodone
oxycodone
naloxone
naloxone
naloxone
oxycodone

---
https://www.inesss.qc.ca/fileadmin/doc/INESSS/Rapports/Medicaments/Naloxone_fiche-synthese_VF.pdf
2018
false
false
false
Canada
French
cardiopulmonary resuscitation
Overdose of opiate (disorder)
practice guideline
guidelines for drug use
naloxone
narcotic antagonists
poisoning
injections, intramuscular
administration, intranasal
opioids
morphine derivatives
analgesics, opioid

---
https://www.ansm.sante.fr/actualites/spray-nasal-de-naloxone-nalscue-entree-en-vigueur-de-lamm-le-8-janvier-2018
2018
false
false
false
France
French
drug information
drug approval
france
naloxone
administration, intranasal
nasal sprays
narcotic antagonists
emergency treatment
Naloxone Hydrochloride
naloxone
poisoning
opiate alkaloids
drug users
Overdose of opiate (disorder)
patient education as topic

---
https://www.has-sante.fr/portail/jcms/c_2829037/fr/nalscue
2018
false
false
false
false
France
French
evaluation of the transparency committee
administration, intranasal
naloxone
naloxone
naloxone
treatment outcome
narcotic antagonists
narcotic antagonists
insurance, health, reimbursement
adult
nasal sprays
child
infant
emergency treatment
adolescent
opiate alkaloids
poisoning
Overdose of opiate (disorder)

---
http://canadiensensante.gc.ca/recall-alert-rappel-avis/hc-sc/2017/63784a-fra.php
2017
false
false
false
Canada
French
English
drug approval
canada
drug information
administration, intranasal
naloxone
nasal sprays
naloxone
narcotic antagonists
Overdose of opiate (disorder)
opiate alkaloids

---
https://www.ema.europa.eu/medicines/human/EPAR/Nyxoid
2017
false
false
false
United Kingdom
French
English
syndication feed
summary of product characteristics
package leaflet
naloxone
administration, intranasal
nasal sprays
drug approval
europe
treatment outcome
naloxone
emergency treatment
narcotic antagonists
narcotic antagonists
heroin
morphine
Morphine overdose (disorder)
Heroin overdose (disorder)
poisoning
adolescent
adult
respiratory depression
Drug-induced central nervous system depression (disorder)
morphine derivatives
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
naloxone
respiratory insufficiency

---
http://www.has-sante.fr/portail/jcms/c_2617874/fr/targinact
2016
false
France
French
evaluation of the transparency committee
Naloxone Hydrochloride
Oxycodone Hydrochloride
restless legs syndrome
oxycodone naloxone combination
drug combinations
Delayed-Action preparations
oxycodone
naloxone
administration, oral
narcotics
insurance, health, reimbursement
adult
treatment outcome
drug combinations

---
http://www.has-sante.fr/portail/jcms/c_2040129/fr/targinact
http://www.has-sante.fr/portail/jcms/c_1189043/targinact
http://www.has-sante.fr/portail/jcms/c_2040129/fr/targinact-oxycodone/naloxone-opioide-en-association
2015
false
France
French
evaluation of the transparency committee
guidelines for drug use
osteoarthritis, hip
osteoarthritis, knee
low back pain
Cancer Pain Management
Cancer Pain
Cancer Pain
Cancer pain
administration, oral
insurance, health, reimbursement
naloxone
drug combinations
oxycodone
analgesics, opioid
narcotics
narcotic antagonists
oxycodone and naloxone
Delayed-Action preparations
pain
adult
oxycodone naloxone combination
aged
treatment outcome
neoplasms
constipation
oxycodone
clinical trials as topic

---
http://www.cnerea.fr/UserFiles/File/national/desc-des/livre-masson-2015/intox/antidotes.pdf
2015
true
false
false
France
French
educational course
French pre-residency program examination
poisoning
antidotes
antidotes
antidotes
charcoal
toxicology
acetylcysteine
flumazenil
naloxone
antidotes

---
https://www.inspq.qc.ca/toxicologie-clinique/nouveau-dispositif-auto-injecteur-pour-l-administration-de-naloxone-approuve-aux-etats-unis
2014
false
true
false
Canada
French
journal article
self administration
naloxone
united states
naloxone
self administration

---
https://www.inspq.qc.ca/toxicologie-clinique/enonce-de-position-sur-l-elargissement-de-l-acces-la-naloxone-aux-etats-unis
2014
false
true
false
Canada
French
journal article
naloxone
naloxone
naloxone
united states

---
http://www.pharmactuel.com/index.php/pharmactuel/article/view/891
2013
false
Canada
French
journal article
drug incompatibility
naloxone
injections, intravenous
naloxone

---
http://www.cochrane.org/fr/CD003483
2013
United Kingdom
France
French
french abstract
meta-analysis
infant, newborn
naloxone
narcotic antagonists
analgesics, opioid
labor pain
prenatal exposure delayed effects

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=62089059
2012
France
summary of product characteristics
package leaflet
tablets
naloxone
oxycodone naloxone combination
oxycodone

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=69468019
2012
France
summary of product characteristics
package leaflet
oxycodone
tablets
oxycodone naloxone combination
naloxone

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=64381336
2012
France
summary of product characteristics
package leaflet
sublingual gland
buprenorphine
naloxone
tablets

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=63827255
2012
France
summary of product characteristics
package leaflet
naloxone
tablets
sublingual gland
buprenorphine

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=62236203
2012
France
summary of product characteristics
package leaflet
oxycodone
oxycodone naloxone combination
naloxone
tablets

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=67476960
2012
France
summary of product characteristics
package leaflet
injections
naloxone

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=66883896
2012
France
summary of product characteristics
package leaflet
injections
naloxone

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=64456251
2012
France
summary of product characteristics
package leaflet
naloxone
injections

---
http://agence-prd.ansm.sante.fr/php/ecodex/extrait.php?specid=63473251
2012
France
summary of product characteristics
package leaflet
naloxone
oxycodone
oxycodone naloxone combination
tablets

---
http://www.has-sante.fr/portail/jcms/c_1230748/targinact-07122011-synthese-ct10871
http://www.has-sante.fr/portail/upload/docs/application/pdf/2012-01/targinact_07_12_2011_avis_ct10861.pdf
http://www.has-sante.fr/portail/jcms/c_1230787/targinact-association-oxycodone/naloxone-antalgique-synthese-d-avis
2011
France
French
evaluation of the transparency committee
guidelines for drug use
Cancer Pain Management
Cancer Pain
oxycodone naloxone combination
oxycodone naloxone combination
drug combinations
Delayed-Action preparations
analgesics, opioid
analgesics, opioid
narcotic antagonists
narcotic antagonists
oxycodone
oxycodone
naloxone
naloxone
administration, oral
oxycodone and naloxone
narcotics
insurance, health, reimbursement
pain
neoplasms
adult
constipation
constipation
treatment outcome
randomized controlled trials as topic
cohort studies
Cancer Pain
Cancer pain

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17/05/2024


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