Naloxone - CISMeF

Preferred Label : Naloxone;

NCIt synonyms : Naloxone Base;

NCIt related terms : (-)-Naloxone;

NCIt definition : A thebaine derivate with competitive opioid antagonistic properties. Naloxone reverses the effects of opioid analgesics by binding to the opioid receptors in the CNS, and inhibiting the typical actions of opioid analgesics, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence. Naloxone binds to mu-opioid receptors with a high affinity, and a lesser degree to kappa- and gamma-opioid receptors in the CNS.;

Alternative definition : NCI-GLOSS: A substance that is being studied as a treatment for constipation caused by narcotic medications. It belongs to the family of drugs called narcotic antagonists.;

UNII : 36B82AMQ7N;

InChIKey : UZHSEJADLWPNLE-GRGSLBFTSA-N;

CAS number : 465-65-6;

Chemical formula : C19H21NO4;

ChEBI ID : CHEBI:7459;

Codes from synonyms : NSC0070413; 30318; CDR0000045228;

Details

Origin ID

C62054;

UMLS CUI

C0027358;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Naloxone [ICD-11 Extension code]
- Naloxone [LOINC component]
- Naloxone (substance) [SNOMED CT concept]
- Product containing naloxone (medicinal product) [SNOMED CT concept]
- naloxone [ATC Code]
- naloxone [ATC Code]
- naloxone [Substance BNPC]
- naloxone [MeSH concept]
- naloxone [MeSH Descriptor]
- naloxone [SNOMED Notion]
Validated automatic mappings to BTNT
- naloxone [ATC Code]
- naloxone [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Naloxone Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Naloxone Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

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