Preferred Label : Naloxone Hydrochloride;
NCIt synonyms : Naloxone;
NCIt related terms : Narcan;
NCIt definition : The hydrochloride salt of naloxone, a thebaine derivate with opioid antagonist activity.
Naloxone binds to opioid receptors in the CNS in a competitive manner, reversing or
inhibiting characteristic opioid effects, including analgesia, euphoria, sedation,
respiratory depression, miosis, bradycardia, and physical dependence. This agent binds
to mu-opioid receptors with a high affinity, and a lesser degree to kappa- and gamma-opioid
receptors.;
UNII : F850569PQR;
InChIKey : RGPDIGOSVORSAK-STHHAXOLSA-N;
CAS number : 357-08-4;
Drug name : Narcan;
Chemical formula : C19H21NO4.HCl;
NSC code : 70413;
Codes from synonyms : NSC0070413;
Origin ID : C678;
UMLS CUI : C0700549;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
