" /> Fentanyl - CISMeF





Preferred Label : Fentanyl;

NCIt synonyms : N-(1-phenethylpiperidin-4-yl)-N-phenylpropionamide;

NCIt definition : A synthetic, lipophilic phenylpiperidine opioid agonist with analgesic and anesthetic properties. Fentanyl selectively binds to and activates the mu-receptor in the central nervous system (CNS) thereby mimicking the effects of endogenous opiates. Activation of the mu-subtype opioid receptor stimulates the exchange of GTP for GDP on the G-protein complex and subsequently inhibits adenylate cyclase. This causes a decrease in intracellular cAMP which inhibits cAMP-mediated calcium influx into the cell via the calcium channels and thereby results in hyperpolarization and reduced neuronal excitability.;

UNII : UF599785JZ;

InChIKey : PJMPHNIQZUBGLI-UHFFFAOYSA-N;

CAS number : 437-38-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 437-38-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Duragesic; Abstral;

Chemical formula : C22H28N2O;

ChEBI ID : CHEBI:119915;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
05/05/2024


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.