Fentanyl - CISMeF

Preferred Label : Fentanyl;

NCIt synonyms : N-(1-phenethylpiperidin-4-yl)-N-phenylpropionamide;

NCIt definition : A synthetic, lipophilic phenylpiperidine opioid agonist with analgesic and anesthetic properties. Fentanyl selectively binds to and activates the mu-receptor in the central nervous system (CNS) thereby mimicking the effects of endogenous opiates. Activation of the mu-subtype opioid receptor stimulates the exchange of GTP for GDP on the G-protein complex and subsequently inhibits adenylate cyclase. This causes a decrease in intracellular cAMP which inhibits cAMP-mediated calcium influx into the cell via the calcium channels and thereby results in hyperpolarization and reduced neuronal excitability.;

UNII : UF599785JZ;

InChIKey : PJMPHNIQZUBGLI-UHFFFAOYSA-N;

CAS number : 437-38-7;

Drug name : Duragesic; Abstral;

Chemical formula : C22H28N2O;

ChEBI ID : CHEBI:119915;

Details

Origin ID

C494;

UMLS CUI

C0015846;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Fentanyl [ICD-11 Extension code]
- Fentanyl (substance) [SNOMED CT concept]
- Product containing fentanyl (medicinal product) [SNOMED CT concept]
- fentaNYL [LOINC component]
- fentanyl [ATC Code]
- fentanyl [ATC Code]
- fentanyl [Substance BNPC]
- fentanyl [SNOMED Notion]
- fentanyl [MeSH concept]
- fentanyl [MeSH Descriptor]
Validated automatic mappings to BTNT
- fentanyl [ATC Code]
- fentanyl [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
- Cytochrome P450 3A5 [NCIt concept]
- Cytochrome P450 3A7 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_salt_form
- Fentanyl Citrate [NCIt concept]
- Fentanyl Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Fentanyl Citrate [NCIt concept]
- Fentanyl Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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