Sirolimus - CISMeF

Preferred Label : Sirolimus;

NCIt synonyms : RAPA; 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,2;

NCIt related terms : RAPAMYCIN; Rapamune;

NCIt definition : A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation and inhibition of antibody production. (NCI04);

Alternative definition : NCI-GLOSS: A drug used to keep the body from rejecting organ and bone marrow transplants. Rapamune blocks certain white blood cells that can reject foreign tissues and organs. It also blocks a protein that is involved in cell division. It is a type of antibiotic, a type of immunosuppressant, and a type of serine/threonine kinase inhibitor. Rapamune was previously called rapamycin.;

UNII : W36ZG6FT64;

InChIKey : QFJCIRLUMZQUOT-HPLJOQBZSA-N;

CAS number : 53123-88-9;

Drug name : Rapamune;

Molecule name : AY 22989; WY-090217; SILA 9268A; AY-22989; SILA-9268A; WY 090217;

Chemical formula : C51H79NO13;

NSC code : 226080;

ChEBI ID : CHEBI:9168;

Codes from synonyms : NSC0226080; CDR0000285947; CDR0000045513; 20504; CDR0000580375; 468;

Details

Origin ID

C1212;

UMLS CUI

C0072980;

Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing sirolimus (medicinal product) [SNOMED CT concept]
- Sirolimus [LOINC component]
- Sirolimus (substance) [SNOMED CT concept]
- sirolimus [ATC Code]
- sirolimus [ATC Code]
- sirolimus [Substance BNPC]
- sirolimus [ATC Code]
- sirolimus [MeSH concept]
- sirolimus [MeSH Descriptor]
Validated automatic mappings to BTNT
- sirolimus [ATC Code]
- sirolimus [ATC Code]
- sirolimus [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
- Cytochrome P450 3A5 [NCIt concept]
- Cytochrome P450 3A7 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_target
- Peptidyl-Prolyl Cis-Trans Isomerase FKBP1A [NCIt concept]
- Serine/Threonine-Protein Kinase mTOR [NCIt concept]
is_component_of_chemotherapy_regimen
- Allogeneic Lymphocytes/Cyclosporine/Sirolimus [NCIt concept]
- Cyclosporine/Methotrexate/Sirolimus [NCIt concept]
- Cyclosporine/Sirolimus [NCIt concept]
- Imatinib/Sirolimus Regimen [NCIt concept]
- Prednisone/Sirolimus Regimen [NCIt concept]
- Sirolimus Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

You can consult :

recommendations
documents concerning education
documents for patients