sirolimus - CISMeF

Preferred Label : sirolimus;

MeSH definition : A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.;

MeSH synonym : rapamycin;

CISMeF synonym : wyeth brand of sirolimus;

MeSH hyponym : AY 22-989; I-2190A; rapamune; I 2190A; I2190A; AY 22 989; AY 22989;

MeSH Related Number : 53123-88-9 (Sirolimus); 53123-88-9;

Registry Number MeSH : 53123-88-9;

Wikipedia link : https://en.wikipedia.org/wiki/Sirolimus;

Is substance : O;

UNII : W36ZG6FT64;

InChIKey : QFJCIRLUMZQUOT-HPLJOQBZSA-N;

Details

Origin ID

D020123;

UMLS CUI

C0072980;

ATC code(s)
- sirolimus [ATC Code]
- sirolimus [ATC Code]
- sirolimus [ATC Code]
Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analogs and derivatives [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- economics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- urine [MeSH Qualifier]
CISMeF manual mappings
- sirolimus [Substance BNPC]
Currated CISMeF NLP mapping
- Sirolimus [LOINC component]
- Sirolimus [ICD-11 Extension code]
- Sirolimus [SMS substance]
- Sirolimus [NCIt concept]
- Sirolimus (substance) [SNOMED CT concept]
Pharmacological action(s)
- anti-bacterial agents [MeSH Descriptor]
- antibiotics, antineoplastic [MeSH Descriptor]
- antifungal agents [MeSH Descriptor]
- immunosuppressive agents [MeSH Descriptor]
Record concept(s)
- AY 22-989 [MeSH concept]
- I-2190A [MeSH concept]
- rapamune [MeSH concept]
- sirolimus [MeSH concept]
Related MeSH Supplementary Concept(s)
- 15-deoxo-7,32-O-didesmethylrapamycin [MeSH Supplementary Concept]
- AP 21967 [MeSH Supplementary Concept]
- RapaLink-1 [MeSH Supplementary Concept]
- SAR943 [MeSH Supplementary Concept]
- SDZ RAD 223-756 [MeSH Supplementary Concept]
- WAY 124466 [MeSH Supplementary Concept]
- demethoxyrapamycin [MeSH Supplementary Concept]
- homotemsirolimuse A [MeSH Supplementary Concept]
- homotemsirolimuse B [MeSH Supplementary Concept]
- homotemsirolimuse C [MeSH Supplementary Concept]
- pre-rapamycin [MeSH Supplementary Concept]
- rapamycin tris-epoxide metabolite [MeSH Supplementary Concept]
- rapamycin-28-N,N-dimethylglycinate [MeSH Supplementary Concept]
- ridaforolimus [MeSH Supplementary Concept]
- temsirolimus [MeSH Supplementary Concept]
- triolimus [MeSH Supplementary Concept]
- umirolimus [MeSH Supplementary Concept]
- zotarolimus [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing sirolimus (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing sirolimus (medicinal product) [SNOMED CT concept]
- Sirolimus [NCIt concept]
- Sirolimus [LOINC component]
- Sirolimus (substance) [SNOMED CT concept]
- sirolimus [ATC Code]
- sirolimus [ATC Code]
- sirolimus [Substance BNPC]
- sirolimus [ATC Code]
Validated automatic mappings to BTNT
- sirolimus [ATC Code]
- sirolimus [ATC Code]
- sirolimus [ATC Code]

Keyword's position in hierarchy(ies) :

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