" /> Irinotecan Hydrochloride - CISMeF





Preferred Label : Irinotecan Hydrochloride;

NCIt synonyms : Camptothecin-11; Irinotecan; Irinotecan Hydrochloride Trihydrate; Irinotecan Monohydrochloride Trihydrate;

NCIt related terms : Camptosar; Camptothecin 11; CPT 11;

NCIt definition : The hydrochloride salt of a semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent.;

Alternative definition : NCI-GLOSS: A drug used alone or with other drugs to treat colon cancer or rectal cancer that has spread to other parts of the body or has come back after treatment with fluorouracil. It is also being studied in the treatment of other types of cancer. Camptosar blocks certain enzymes needed for cell division and DNA repair, and it may kill cancer cells. It is a type of topoisomerase inhibitor and a type of camptothecin analog.;

UNII : 042LAQ1IIS;

InChIKey : KLEAIHJJLUAXIQ-JDRGBKBRSA-N;

CAS number : 136572-09-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 136572-09-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Campto; Camptosar; Irinomedac;

Molecule name : U-101440E; CPT-11;

Chemical formula : C33H38N4O6.HCl.3H2O;

Codes from synonyms : CDR0000635812; CDR0000635811; CDR0000044427; NSC0616348;

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06/05/2024


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