NCIt related terms : Camptosar; Camptothecin 11; CPT 11;
NCIt definition : The hydrochloride salt of a semisynthetic derivative of camptothecin, a cytotoxic,
quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan,
a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin
(SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than
its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing
the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that
inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis
is necessary for irinotecan to exert its cytotoxic effects, it is classified as an
S-phase-specific agent.;
Alternative definition : NCI-GLOSS: A drug used alone or with other drugs to treat colon cancer or rectal cancer
that has spread to other parts of the body or has come back after treatment with fluorouracil.
It is also being studied in the treatment of other types of cancer. Camptosar blocks
certain enzymes needed for cell division and DNA repair, and it may kill cancer cells.
It is a type of topoisomerase inhibitor and a type of camptothecin analog.;
UNII : 042LAQ1IIS;
InChIKey : KLEAIHJJLUAXIQ-JDRGBKBRSA-N;
CAS number : 136572-09-3;
Drug name : Campto; Camptosar; Irinomedac;
Molecule name : U-101440E; CPT-11; U 101440E;
Chemical formula : C33H38N4O6.HCl.3H2O;
Codes from synonyms : CDR0000635812; CDR0000635811; CDR0000044427; NSC0616348;