Preferred Label : Irinotecan;
NCIt synonyms : 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin; ( )-(4S)-4,11-diethyl-4-hydroxy-9-[(4-piperidino-piperidino)carbonyloxy]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinol-3,14,(4H,12H)-dione; [1,4'-bipiperidine]-1'-carboxylic acid (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl
ester; ( )-7-ethyl-10-hydroxycamptothecine 10-[1,4'-bipiperidine]-1'-carboxylate; Irinotecan Base;
NCIt definition : A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid
extracted from the Asian tree Camptotheca acuminata. Irinotecan, a prodrug, is converted
to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting
enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits
topoisomerase I activity by stabilizing the cleavable complex between topoisomerase
I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic
cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its
cytotoxic effects, it is classified as an S-phase-specific agent.;
Alternative definition : NCI-GLOSS: The active ingredient in a drug used alone or with other drugs to treat
colon cancer or rectal cancer that has spread to other parts of the body or has come
back after treatment with fluorouracil. It is also being studied in the treatment
of other types of cancer. Irinotecan blocks certain enzymes needed for cell division
and DNA repair, and it may kill cancer cells. It is a type of topoisomerase inhibitor
and a type of camptothecin analog.;
UNII : 7673326042;
InChIKey : UWKQSNNFCGGAFS-XIFFEERXSA-N;
CAS number : 97682-44-5;
Chemical formula : C33H38N4O6;
NSC code : 728073; 616348;
Codes from synonyms : CDR0000045391; NSC0616348; 280;
Origin ID : C62040;
UMLS CUI : C0123931;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- chemical_or_drug_is_metabolized_by_enzyme
- concept_is_in_subset
- has_salt_form
- has_target
- is_component_of_chemotherapy_regimen
- is_free_acid_or_base_form_of
