Quinine - CISMeF

Preferred Label : Quinine;

NCIt synonyms : QUIN;

NCIt related terms : (-)-Quinine;

NCIt definition : A quinidine alkaloid isolated from the bark of the cinchona tree. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04);

UNII : A7V27PHC7A;

InChIKey : LOUPRKONTZGTKE-WZBLMQSHSA-N;

CAS number : 130-95-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 130-95-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C20H24N2O2;

NSC code : 192949;

ChEBI ID : CHEBI:15854;

Codes from synonyms : NSC0005362; NSC0192949; 424;

Details

Origin ID

C794;

UMLS CUI

C0034417;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing quinine (medicinal product) [SNOMED CT concept]
- Quinine [ICD-11 Extension code]
- Quinine (substance) [SNOMED CT concept]
- quiNINE [LOINC component]
- quinine [ATC Code]
- quinine [Substance BNPC]
- quinine [MeSH Descriptor]
- quinine [MeSH concept]
- quinine [SNOMED Notion]
Validated automatic mappings to BTNT
- quinine [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
- Cytochrome P450 3A5 [NCIt concept]
- Cytochrome P450 3A7 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Quinine Glycerophosphate [NCIt concept]
- Quinine Hydrochloride [NCIt concept]
- Quinine Sulfate [NCIt concept]
is_component_of_chemotherapy_regimen
- Cyclophosphamide/Dexamethasone/Doxorubicin/Quinine/Verapamil/Vincristine [NCIt concept]
- Cyclophosphamide/Doxorubicin/Etoposide/Medroxyprogesterone/Quinine [NCIt concept]
- Dexamethasone/Doxorubicin/Prednisone/Quinine/Vincristine [NCIt concept]
- Dexamethasone/Doxorubicin/Quinine/Verapamil/Vincristine [NCIt concept]
- Paclitaxel/Quinine [NCIt concept]
is_free_acid_or_base_form_of
- Quinine Glycerophosphate [NCIt concept]
- Quinine Hydrochloride [NCIt concept]
- Quinine Sulfate [NCIt concept]

Keyword's position in hierarchy(ies) :

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