NCIt definition : A quinidine alkaloid isolated from the bark of the cinchona tree. Quinine has many
mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism;
disruption of DNA replication and transcription via DNA intercalation; and reduction
of the excitability of muscle fibers via alteration of calcium distribution. This
agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in
multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents.
(NCI04);
UNII : A7V27PHC7A;
InChIKey : LOUPRKONTZGTKE-WZBLMQSHSA-N;
CAS number : 130-95-0;
Chemical formula : C20H24N2O2;
NSC code : 192949;
ChEBI ID : CHEBI:15854;
Codes from synonyms : NSC0005362; NSC0192949; 424;