NCIt definition : The sulfate salt form of the quinidine alkaloid isolate quinine. Quinine has many
mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism;
disruption of DNA replication and transcription via DNA intercalation; and reduction
of the excitability of muscle fibers via alteration of calcium distribution. This
agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in
multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents.
(NCI04);