Cilostazol - CISMeF

Preferred Label : Cilostazol;

NCIt synonyms : 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone;

NCIt definition : A quinolinone derivative and cellular phosphodiesterase inhibitor, more specific for phosphodiesterase III (PDE III). Although the exact mechanism of action of is unknown, cilostazol and its metabolites appears to inhibit PDE III activity, thereby suppressing cyclic adenosine monophosphate (cAMP) degradation. This results in an increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation.;

UNII : N7Z035406B;

InChIKey : RRGUKTPIGVIEKM-UHFFFAOYSA-N;

CAS number : 73963-72-1;

Drug name : Pletal;

Chemical formula : C20H27N5O2;

ChEBI ID : CHEBI:31401;

Codes from synonyms : 102;

Details

Origin ID

C1051;

UMLS CUI

C0055729;

Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Cilostazol [MeSH Descriptor]
- Cilostazol (substance) [SNOMED CT concept]
- Product containing cilostazol (medicinal product) [SNOMED CT concept]
- cilostazol [ATC Code]
- cilostazol [MeSH concept]
Validated automatic mappings to BTNT
- cilostazol [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
- Cytochrome P450 3A5 [NCIt concept]
- Cytochrome P450 3A7 [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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