" /> Oral Irinotecan Hydrochloride Formulation VAL-413 - CISMeF





Preferred Label : Oral Irinotecan Hydrochloride Formulation VAL-413;

NCIt synonyms : Oral Irinotecan VAL-413; Oral Irinotecan HCl Formulation VAL-413;

NCIt definition : An orally bioavailable flavored formulation composed of the hydrochloride salt form of irinotecan, a semisynthetic derivative of camptothecin, with potential antineoplastic activity. Upon oral administration of oral irinotecan HCl formulation VAL-413, irinotecan is converted to the biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. In turn, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex of topoisomerase I and DNA, resulting in DNA breaks. This results in an inhibition of DNA replication and an induction of apoptosis in cancer cells. VAL-413 may improve tolerability of oral irinotecan and improve compliance.;

Drug name : Orotecan;

Molecule name : VAL 413; VAL-413;

NCI Metathesaurus CUI : CL1794005;

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07/05/2024


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