NCIt definition : A short-acting benzodiazepine derivative with an imidazole structure and with anxiolytic,
amnestic, hypnotic, anticonvulsant and sedative properties. Midazolam exerts its effect
by binding to the benzodiazepine receptor at the gamma-aminobutyric acid (GABA) receptor-chloride
ionophore complex in the central nervous system (CNS). This leads to an increase in
the opening of chloride channels, membrane hyperpolarization and increases the inhibitory
effect of GABA in the CNS. Midazolam may also interfere with the reuptake of GABA,
thereby causing accumulation of GABA in the synaptic cleft.;
Alternative definition : NCI-GLOSS: A drug used to treat anxiety and tension and to relax muscles. It is also
being studied in the treatment of nausea and vomiting caused by some cancer treatments.
It is a type of benzodiazepine.;