Dapsone - CISMeF

Preferred Label : Dapsone;

NCIt synonyms : 4,4'-Sulfonylbisbenzamine; Croysulfone; DDS; Sulphadione; DADPS; Novophone; 4,4'-Sulfonylbisbenzeneamine; Bis(4-aminophenyl)sulfone;

NCIt related terms : Diphenasone; Bis(4-aminophenyl) sulfone; Eporal; 4,4'-Sulfonyldianiline; 4,4'-Sulfonylbis[benzenamine]; 1358F; Avlosulfon; Disulone; Dumitone; Sulfona-MAE;

NCIt definition : A synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties. As a structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Although the exact mechanism through which dapsone exerts its anti-inflammatory activity has yet to be fully elucidated, this agent interferes with the activation and oxidative damage of myeloperoxidase in neutrophils and inhibits the integrin-mediated adherence and chemotaxis of neutrophils. Dapsone's anti-inflammatory activities may contribute to the effects seen upon topical administration.;

Alternative definition : NCI-GLOSS: A drug used to treat acne. It is also used to treat other types of skin diseases and certain bacterial infections, such as leprosy. It blocks bacteria from making a substance that they need to grow. Dapsone is a type of antibacterial agent and a type of anti-inflammatory agent.;

UNII : 8W5C518302;

InChIKey : MQJKPEGWNLWLTK-UHFFFAOYSA-N;

CAS number : 80-08-0;

Drug name : Undolac; Avlosulfon; Eporal; Disulone; Aczone;

Molecule name : 1358F;

Chemical formula : C12H12N2O2S;

NSC code : 6091;

ChEBI ID : CHEBI:4325;

Codes from synonyms : NSC0006091; 01594; CDR0000661174; 138;

Details

Origin ID

C415;

UMLS CUI

C0010980;

Automatic exact mappings (from CISMeF team)
- disulone [MeSH concept]
False automatic mappings
- Death diagnosis (contextual qualifier) (qualifier value) [SNOMED CT concept]
- Denys-drash syndrome [OMIM Phenotype]
- Deoxy adenosine diphosphate (substance) [SNOMED CT concept]
- Mohr-tranebjaerg syndrome [OMIM Phenotype]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Dapsone [ICD-11 Extension code]
- Dapsone [LOINC part]
- Dapsone [LOINC component]
- Dapsone (substance) [SNOMED CT concept]
- Product containing dapsone (medicinal product) [SNOMED CT concept]
- dapsone [ATC Code]
- dapsone [ATC Code]
- dapsone [Substance BNPC]
- dapsone [MeSH concept]
- dapsone [MeSH Descriptor]
- dapsone [SNOMED Notion]
Validated automatic mappings to BTNT
- dapsone [ATC Code]
- dapsone [ATC Code]
chemical_or_drug_is_metabolized_by_enzyme
- Cytochrome P450 3A4 [NCIt concept]
- Cytochrome P450 3A5 [NCIt concept]
- Cytochrome P450 3A7 [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Dapsone/Trimetrexate Glucuronate [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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