NCIt definition : A quinazoline folate analogue with antineoplastic activity. After transport into cells
via the reduced folate carrier, raltitrexed undergoes intracellular polyglutamation
and blocks the folate-binding site of thymidylate synthase, thereby inhibiting tetrahydrofolate
activity and DNA replication and repair and resulting in cytotoxicity. (NCI04);
Alternative definition : NCI-GLOSS: An anticancer drug that stops tumor cells from growing by blocking the
ability of cells to make DNA. It belongs to the family of drugs called thymidylate
synthase inhibitors.;
UNII : FCB9EGG971;
InChIKey : IVTVGDXNLFLDRM-HNNXBMFYSA-N;
CAS number : 112887-68-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 112887-68-0
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G-SRS /a ;
Molecule name : ZD 1694; ICI D1694; D1694; ZD-1694;
Chemical formula : C21H22N4O6S;
NSC code : 639186;
Codes from synonyms : CDR0000045528; CDR0000044456; 431;