" /> Raltitrexed - CISMeF





Preferred Label : Raltitrexed;

NCIt synonyms : N-[[5-[[(1,4-Dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-L-glutamic Acid; N-(5-[N-(3,4-Dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl)-L-glutamic Acid;

NCIt related terms : ICI D1694;

NCIt definition : A quinazoline folate analogue with antineoplastic activity. After transport into cells via the reduced folate carrier, raltitrexed undergoes intracellular polyglutamation and blocks the folate-binding site of thymidylate synthase, thereby inhibiting tetrahydrofolate activity and DNA replication and repair and resulting in cytotoxicity. (NCI04);

Alternative definition : NCI-GLOSS: An anticancer drug that stops tumor cells from growing by blocking the ability of cells to make DNA. It belongs to the family of drugs called thymidylate synthase inhibitors.;

UNII : FCB9EGG971;

InChIKey : IVTVGDXNLFLDRM-HNNXBMFYSA-N;

CAS number : 112887-68-0;

Molecule name : ZD 1694; ICI D1694; D1694; ZD-1694;

Chemical formula : C21H22N4O6S;

NSC code : 639186;

Codes from synonyms : CDR0000045528; CDR0000044456; 431;

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30/05/2025


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