Preferred Label : Raltitrexed Disodium;
NCIt synonyms : L-glutamic Acid, N-((5-(((3,4-Dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl)methylamino)-2-thienyl)carbonyl)-,
Disodium Salt;
NCIt definition : The disodium salt form of raltitrexed, a quinazoline folate analogue, with potential
antineoplastic activity. Upon administration of raltitrexed, this agent is taken up
by cells via the reduced folate carrier, undergoes intracellular polyglutamation,
and blocks the folate-binding site of thymidylate synthase (TS). This inhibits the
conversion of deoxyuridine monophosphate (dUMP) into deoxythymidine monophosphate
(dTMP) and thus increases dUMP levels and decreases the amount of deoxythymidine triphosphate
(dTTP) available for DNA synthesis. This prevents DNA replication and repair, and
leads to DNA fragmentation and cell death, and results in reduced tumor cell 'proliferation.;
UNII : 50VZN4BPUK;
InChIKey : HYYVJHYAMGPPLX-CKUXDGONSA-L;
Drug name : Tomudex;
NCI Metathesaurus CUI : CL550774;
Origin ID : C148170;
UMLS CUI : C4724870;
Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
