Eniluracil/5-FU Combination Tablet

Preferred Label : Eniluracil/5-FU Combination Tablet;

NCIt synonyms : GW776/5-Fluorouracil; Ethynyluracil/Fluorouracil; GW776/5-FU; 776C85/5-FU; Ethynyluracil Fluorouracil;

NCIt definition : A combination tablet of ethynyluracil and fluorouracil. Fluorouracil is an antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Ethynyluracil is an orally-active fluoropyrimidine analog that inhibits dihydropyrimidine dehydrogenase, the rate-limiting enzyme that catabolizes and inactivates 5-fluorouracil in the liver. This may lead to an increase in the bioavailability and, effectiveness of fluorouracil.;

NSC code : 710026;

Details

Origin ID

C11252;

UMLS CUI

C0393027;

Semantic type(s)
- Therapeutic or Preventive Procedure [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Dihydropyrimidine Dehydrogenase [NADP(+)] [NCIt concept]
- Thymidylate Synthase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
- Nucleoside Analogue Incorporation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- DNA Synthesis Inhibition [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- DNA [NCIt concept]
- Dihydropyrimidine Dehydrogenase [NADP(+)] [NCIt concept]

Keyword's position in hierarchy(ies) :

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