Dihydropyrimidine Dehydrogenase [NADP( )]

Preferred Label : Dihydropyrimidine Dehydrogenase [NADP( )];

NCIt synonyms : DPYD; DPD; EC 1.3.1.2; Dihydrothymine Dehydrogenase; Dihydrouracil Dehydrogenase; Dihydropyrimidine Dehydrogenase; DHPDHase;

NCIt definition : Dihydropyrimidine dehydrogenase [NADP( )] (1025 aa, 111 kDa) is encoded by the human DPYD gene. This protein is involved in the degradation of pyrimidines.;

NCIt note : Dihydropyrimidine dehydrogenase [NADP( )] can catabolize fluorouracil-based chemotherapy drugs. Therefore the expression and activity levels of this enzyme affect therapeutic efficacy and toxicity in patients receiving this type of chemotherapy.;

Details

Origin ID

C17290;

UMLS CUI

C5441758;

Automatic exact mappings (from CISMeF team)
- AAH3 protein, S pombe [MeSH Supplementary Concept]
- AAO1 protein, arabidopsis [MeSH Supplementary Concept]
- AAO3 protein, arabidopsis [MeSH Supplementary Concept]
- AAO4 protein, arabidopsis [MeSH Supplementary Concept]
- AASDH protein, human [MeSH Supplementary Concept]
- ALDH16A1 protein, human [MeSH Supplementary Concept]
- ALDH1A1 protein, human [MeSH Supplementary Concept]
- ALDH1A1 protein, mouse [MeSH Supplementary Concept]
- ALDH1B1 protein, human [MeSH Supplementary Concept]
- ALDH2 protein, human [MeSH Supplementary Concept]
- ALDH2 protein, mouse [MeSH Supplementary Concept]
- ALDH3-1 protein, soybean [MeSH Supplementary Concept]
- ALDH3A1 protein, human [MeSH Supplementary Concept]
- ALDH3I1 protein, arabidopsis [MeSH Supplementary Concept]
- ALDH7A1 protein, human [MeSH Supplementary Concept]
- ALDH7B4 protein, arabidopsis [MeSH Supplementary Concept]
- AMY1.2 protein, hordeum vulgare [MeSH Supplementary Concept]
- AMY1A protein, human [MeSH Supplementary Concept]
- AMY1B protein, human [MeSH Supplementary Concept]
- AMY1C protein, human [MeSH Supplementary Concept]
- AMY2A protein, human [MeSH Supplementary Concept]
- AMY2B protein, human [MeSH Supplementary Concept]
- AOX1 protein, human [MeSH Supplementary Concept]
- AOX2 protein, mouse [MeSH Supplementary Concept]
- Acetyl-CoA hydrolase [MeSH Descriptor]
- Aldh2 protein, rat [MeSH Supplementary Concept]
- Aldh3a1 protein, mouse [MeSH Supplementary Concept]
- Aldh7a1 protein, mouse [MeSH Supplementary Concept]
- Amy1 protein, mouse [MeSH Supplementary Concept]
- Amy2a3 protein, rat [MeSH Supplementary Concept]
- Amy2a5 protein, mouse [MeSH Supplementary Concept]
- Aox1 protein, mouse [MeSH Supplementary Concept]
- Aox1protein, rat [MeSH Supplementary Concept]
- Aox2 protein, rat [MeSH Supplementary Concept]
- Dihydropyrimidine dehydrogenase [OMIM gene]
- FIS1 protein, linum usitatissimum [MeSH Supplementary Concept]
- L-Lactate dehydrogenase (Cytochrome) [MeSH Descriptor]
- MAK31 protein, S cerevisiae [MeSH Supplementary Concept]
- MEC-6 protein, C elegans [MeSH Supplementary Concept]
- Methylmalonyl-CoA carboxytransferase [MeSH Supplementary Concept]
- NAGS protein, human [MeSH Supplementary Concept]
- Pon1 protein, rat [MeSH Supplementary Concept]
- aldehyde dehydrogenase [MeSH Descriptor]
- aldehyde oxidase [MeSH Descriptor]
- aldh1a2 protein, xenopus [MeSH Supplementary Concept]
- alpha-Amylases [MeSH Descriptor]
- alpha-amylase carboxy terminal propeptide, pseudoalteromonas haloplanktis [MeSH Supplementary Concept]
- alpha-amylase, bacillus licheniformis [MeSH Supplementary Concept]
- amino-acid n-acetyltransferase [MeSH Descriptor]
- amyrel protein, drosophila [MeSH Supplementary Concept]
- arylesterase [MeSH Supplementary Concept]
- aspartyl semialdehyde dehydrogenase, helicobacter pylori [MeSH Supplementary Concept]
- dermatophagoides pteronyssinus antigen p 4 [MeSH Supplementary Concept]
- dihydropyrimidine dehydrogenase [HGNC gene]
- dihydropyrimidine dehydrogenase [ORDO Gene]
- dihydropyrimidine dehydrogenase (NADP+) activity [GO term]
- dihydrouracil dehydrogenase (NAD+) activity [GO term]
- dihydrouracil dehydrogenase (NADP) [MeSH Descriptor]
- dihydrouracil dehydrogenase (NADP) [MeSH concept]
- dihydrouracil dehydrogenase (nad+) [MeSH Descriptor]
- gamma-trimethylaminobutyraldehyde dehydrogenase, mouse [MeSH Supplementary Concept]
- lldD protein, E coli [MeSH Supplementary Concept]
- long-chain-aldehyde dehydrogenase [MeSH Supplementary Concept]
- nags protein, mouse [MeSH Supplementary Concept]
- pancreatic alpha-Amylases [MeSH Descriptor]
- piratoxin I [MeSH Supplementary Concept]
- reduced epidermal fluorescence1 protein, arabidopsis [MeSH Supplementary Concept]
- salivary alpha-Amylases [MeSH Descriptor]
Currated CISMeF NLP mapping
- Dihydropyrimidine dehydrogenase (substance) [SNOMED CT concept]
OMIM relation
- Dihydropyrimidine dehydrogenase [OMIM gene]
See also inter- (CISMeF)
- Dihydropyrimidine dehydrogenase deficiency [ICD-11 More detail]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- Dihydropyrimidine dehydrogenase (substance) [SNOMED CT concept]
- Dihydrouracil dehydrogenase (nicotinamide adenine dinucleotide phosphate ^+^) (substance) [SNOMED CT concept]
- dihydrouracil dehydrogenase (NADP) [MeSH Descriptor]
- dihydrouracil dehydrogenase (NADP) [MeSH concept]
- dihydrouracil dehydrogenase (nadp+) [SNOMED Notion]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- DPYD Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Eniluracil/5-FU Combination Tablet [NCIt concept]
gene_product_has_gene_product_variant
- DPYD NP_000101.2:p.D949V [NCIt concept]
- DPYD NP_000101.2:p.I543V [NCIt concept]
- DPYD NP_000101.2:p.I560S [NCIt concept]
- DPYD NP_000101.2:p.Y186C [NCIt concept]
- DPYD Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Disease Marker [NCIt concept]
gene_product_is_element_in_pathway
- Beta-Alanine Metabolism Pathway [NCIt concept]
- Pantothenate and CoA Biosynthesis Pathway [NCIt concept]
- Pyrimidine Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Catabolic Process [NCIt concept]
- Nucleotide Metabolic Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
is_target
- Eniluracil [NCIt concept]
- Eniluracil/5-FU Combination Tablet [NCIt concept]
- dUTPase/DPD Inhibitor TAS-114 [NCIt concept]

Keyword's position in hierarchy(ies) :

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