" /> Edatrexate - CISMeF





Preferred Label : Edatrexate;

NCIt synonyms : N-[4-[1-[(2,4-Diamino-6-pteridinyl)-methyl]propyl]benzoyl]-L-glutamic Acid; 10-Ethyl-10-deaza-aminopterin; EDAM; 10-EDAM;

NCIt related terms : N-[4-[1-[(2, 4-Diamino-6-pteridinyl)-methyl]propyl]benzoyl]-L-glutamic acid;

NCIt definition : A polyglutamatable folate antagonist analogue of methotrexate with antineoplastic activity. Edatrexate inhibits dihydrofolate reductase, thereby increasing cellular levels of polyglutamates, inhibiting thymidylate synthase and glycinamide ribonucleotide formyl transferase, impairing synthesis of purine nucleotides and amino acids, and resulting in tumor cell death. Edatrexate may overcome tumor resistance to methotrexate, which loses its activity after it is polyglutamated. (NCI04);

Alternative definition : NCI-GLOSS: An anticancer drug that belongs to a family of drugs called antimetabolites.;

UNII : JT4X6Z1HRR;

InChIKey : FSIRXIHZBIXHKT-MHTVFEQDSA-N;

CAS number : 80576-83-6;

Molecule name : CGP-30694;

Chemical formula : C22H25N7O5;

NSC code : 626715;

Codes from synonyms : NSC0626715; CDR0000045325;

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30/05/2025


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