NCIt related terms : N-[4-[1-[(2, 4-Diamino-6-pteridinyl)-methyl]propyl]benzoyl]-L-glutamic acid;
NCIt definition : A polyglutamatable folate antagonist analogue of methotrexate with antineoplastic
activity. Edatrexate inhibits dihydrofolate reductase, thereby increasing cellular
levels of polyglutamates, inhibiting thymidylate synthase and glycinamide ribonucleotide
formyl transferase, impairing synthesis of purine nucleotides and amino acids, and
resulting in tumor cell death. Edatrexate may overcome tumor resistance to methotrexate,
which loses its activity after it is polyglutamated. (NCI04);
Alternative definition : NCI-GLOSS: An anticancer drug that belongs to a family of drugs called antimetabolites.;