Dihydrofolate Reductase

Preferred Label : Dihydrofolate Reductase;

NCIt synonyms : DHFR; EC 1.5.1.3;

NCIt definition : Dihydrofolate reductase (187 aa, 21 kDa) is encoded by the human DHFR gene. This protein is involved in folate metabolism and the synthesis of nucleotides and glycine.;

Details

Origin ID

C17191;

UMLS CUI

C3853636;

Currated CISMeF NLP mapping
- dihydrofolate reductase [SNOMED Notion]
False automatic mappings
- Dihydrofolate reductase (substance) [SNOMED CT concept]
OMIM relation
- Dihydrofolate reductase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- DHFR Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_affected_by_chemical_or_drug
- Edatrexate [NCIt concept]
- Talotrexin [NCIt concept]
- Talotrexin Ammonium [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- E2F Transcription Factor Pathway [NCIt concept]
- Folate Biosynthesis Pathway [NCIt concept]
- G1/S Checkpoint Pathway [NCIt concept]
- One Carbon Pool by Folate Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Biosynthetic Process [NCIt concept]
- Nucleotide Metabolic Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
is_target
- IGF-methotrexate Conjugate [NCIt concept]
- Methotrexate [NCIt concept]
- Methotrexate Sodium [NCIt concept]
- Pralatrexate [NCIt concept]
- Talotrexin Ammonium [NCIt concept]

Keyword's position in hierarchy(ies) :

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