Preferred Label : Methotrexate;
NCIt synonyms : MTX; Methotrexatum; N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic Acid; Metotrexato; Alpha-Methopterin; Methotrexate Methylaminopterin; 4-Amino-4-deoxy-10-methylpteroyl-L-glutamic Acid; 4-Amino-10-methylfolic Acid;
NCIt related terms : Rheumatrex; CL 14377; Folex; Amethopterin;
NCIt definition : An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities.
Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in
inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition
of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity
although the mechanism(s) of actions is unclear.;
Alternative definition : NCI-GLOSS: A drug used to treat some types of cancer, rheumatoid arthritis, and severe
skin conditions, such as psoriasis. Amethopterin stops cells from making DNA and may
kill cancer cells. It is a type of antimetabolite.;
UNII : YL5FZ2Y5U1;
InChIKey : FBOZXECLQNJBKD-ZDUSSCGKSA-N;
CAS number : 59-05-2;
Drug name : Tremetex; Methotrexate LPF; Lumexon; Emthexat; Brimexate; Fauldexato; Rheumatrex; Emtexate; Medsatrexate; Metex; Methoblastin; Emthexate; Folex PFS; Folex; Amethopterin; Novatrex; Trixilem; Farmitrexat; Ledertrexate; Texate; Mexate-AQ; Lantarel; Trexeron; Mexate; Maxtrex; Metrotex; Abitrexate;
Molecule name : CL-14377; WR-19039;
Chemical formula : C20H22N8O5;
NSC code : 740;
ChEBI ID : CHEBI:44185;
Codes from synonyms : NSC0000740; 05757; CDR0000428246; NSC0027720; CDR0000413957; CDR0000045393; 329;
Origin ID : C642;
UMLS CUI : C0025677;
Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_salt_form
- has_target
- is_component_of_chemotherapy_regimen
- is_free_acid_or_base_form_of
- is_target
https://www.rheuma-net.ch/fr/doc/methotrexat-1/viewdocument/352
2024
Switzerland
guideline
methotrexate
Methotrexate
methotrexate
Background Treatment
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https://dumas.ccsd.cnrs.fr/dumas-04255693
2022
France
dissertations, academic
Treatment
Therapeutic
review literature as topic
rheumatic diseases
rheumatic fever
patient status observation, nos
Satisfaction
Methotrexate
Chronic Graft Versus Host Disease
acquaintance
methotrexate
Patient Observation
Reviewing
patient compliance
methotrexate
insight, nos
Therapeutic Procedure
disease
Rheumatologic Disorder
patient satisfaction
knowledge
rheumatism, nos
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