Methotrexate Sodium

Preferred Label : Methotrexate Sodium;

NCIt synonyms : Sodium Methotrexate;

NCIt definition : The sodium salt of methotrexate, an antimetabolite with antineoplastic and immunomodulating properties. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant properties. (NCI04);

UNII : 3IG1E710ZN;

InChIKey : DASQOOZCTWOQPA-GXKRWWSZSA-L;

CAS number : 7413-34-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 7413-34-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Xatmep; Trexall;

Chemical formula : C20H20N8O5.2Na;

ChEBI ID : CHEBI:50679;

Details

Origin ID

C1735;

UMLS CUI

C0949359;

Automatic exact mappings (from CISMeF team)
- Methotrexate (substance) [SNOMED CT concept]
- Product containing methotrexate (medicinal product) [SNOMED CT concept]
- methotrexate [MeSH Descriptor]
Currated CISMeF NLP mapping
- Methotrexate sodium (substance) [SNOMED CT concept]
- methotrexate sodium [MeSH concept]
See also inter- (CISMeF)
- Product containing methotrexate (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Methotrexate sodium (substance) [SNOMED CT concept]
- methotrexate sodium [MeSH concept]
Validated automatic mappings to BTNT
- disodium n-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-l-glutamate [Substance BNPC]
Validated automatic mappings to NTBT
- Methotrexate (substance) [SNOMED CT concept]
- methotrexate [SNOMED Notion]
- methotrexate [MeSH Descriptor]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_free_acid_or_base_form
- Methotrexate [NCIt concept]
has_target
- Dihydrofolate Reductase [NCIt concept]
is_component_of_chemotherapy_regimen
- ASHAP Alternating with M-BACOS Regimen [NCIt concept]
- BCMF Regimen [NCIt concept]
- BVAM Regimen [NCIt concept]
- Bleomycin/Cisplatin/Cyclophosphamide/Dactinomycin/Doxorubicin/Methotrexate Regimen [NCIt concept]
- Bleomycin/Cyclophosphamide/Fluorouracil/Methotrexate/Vincristine Regimen [NCIt concept]
- CAMELEON Regimen [NCIt concept]
- CMC Alternating with VAP Regimen [NCIt concept]
- CMFH Regimen [NCIt concept]
- COMLA Regimen [NCIt concept]
- Cisplatin/Fluorouracil/Leucovorin/Methotrexate Regimen [NCIt concept]
- Cisplatin/Fluorouracil/Methotrexate Regimen [NCIt concept]
- Cytarabine/Filgrastim/Methotrexate Regimen [NCIt concept]
- DDP-MECY Regimen [NCIt concept]
- Dactinomycin/Doxorubicin/Methotrexate/Vincristine Regimen [NCIt concept]
- Dose-adjusted R-EPOCH Plus High-dose Methotrexate Regimen [NCIt concept]
- Doxorubicin/Etoposide/Methotrexate Regimen [NCIt concept]
- Fluorouracil/Ifosfamide/Mesna/Methotrexate Regimen [NCIt concept]
- Fluorouracil/Leucovorin Calcium/Methotrexate Regimen [NCIt concept]
- High-Dose Methotrexate Regimen [NCIt concept]
- Ibrutinib/High-dose Methotrexate/Rituximab Regimen [NCIt concept]
- LOMAC Regimen [NCIt concept]
- LSA2L2 Regimen [NCIt concept]
- Leucovorin Calcium/Methotrexate Regimen [NCIt concept]
- Lomustine/Methotrexate/Procarbazine Regimen [NCIt concept]
- MACHO Regimen [NCIt concept]
- MMV Regimen [NCIt concept]
- MOAP Regimen [NCIt concept]
- MOMP Regimen [NCIt concept]
- Mercaptopurine/Methotrexate/Tretinoin Regimen [NCIt concept]
- Methotrexate Intra-Cerebrospinal Fluid Regimen [NCIt concept]
- Methotrexate Regimen [NCIt concept]
- Methotrexate/Leucovorin/Vincristine Regimen [NCIt concept]
- PMF Regimen [NCIt concept]
- R-CODOX-M Alternating with R-IVAC Regimen [NCIt concept]
- R-CODOX-M Regimen [NCIt concept]
is_salt_form_of
- Methotrexate [NCIt concept]

Keyword's position in hierarchy(ies) :

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