Glucarpidase - CISMeF

Preferred Label : Glucarpidase;

NCIt synonyms : Carboxypeptidase G2; CPG2; CPDG2; Poly(gamma-glutamic Acid) Endohydrolase; Pteroylpolygammaglutamyl Hydrolase; Acetylaspartylglutamate Dipeptidase;

NCIt related terms : carboxypeptidase-G2;

NCIt definition : A zinc-dependent enzyme isolated from a strain of the bacterium Pseudomonas. Because glucarpidase rapidly hydrolyzes methotrexate into inactive metabolites, it may be useful as a rescue agent for methotrexate-induced nephrotoxicity. In antibody-directed enzyme prodrug therapy (ADEPT), this agent is conjugated with an antibody that binds to a specific tumor cell type, allowing for glucarpidase-catalyzed activation of a co-administered prodrug at the site of the tumor.;

Alternative definition : NCI-GLOSS: A bacterial enzyme that breaks down proteins and other substances, including methotrexate. It is being studied in the treatment of toxic effects caused by methotrexate. It may also help activate certain drugs to kill cancer cells. It is a type of chemoprotective agent and a type of prodrug activator.;

UNII : 2GFP9BJD79;

CAS number : 9074-87-7;

Drug name : Voraxaze; Megludase;

Chemical formula : C20H20O4;

NSC code : 641273; 732443;

Codes from synonyms : CDR0000045384; 247;

Details

Origin ID

C346;

UMLS CUI

C0007072;

Currated CISMeF NLP mapping
- Glucarpidase [ICD-11 Extension code]
- Glucarpidase [SMS substance]
- Glucarpidase (substance) [SNOMED CT concept]
- carboxypeptidase G2 [MeSH concept]
- glucarpidase [MeSH concept]
- glucarpidase [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing glucarpidase (medicinal product) [SNOMED CT concept]
- Voraxaze [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Glucarpidase (substance) [SNOMED CT concept]
- Product containing glucarpidase (medicinal product) [SNOMED CT concept]
- carboxypeptidase G2 [MeSH concept]
- glucarpidase [ATC Code]
- glucarpidase [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- glucarpidase [ATC Code]
chemical_or_drug_has_mechanism_of_action
- Substrate Interaction [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Drug Metabolism Induction [NCIt concept]
- Nephrotoxicity Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Methotrexate [NCIt concept]
is_component_of_chemotherapy_regimen
- Carboxypeptidase-G2/Leucovorin Calcium/Methotrexate [NCIt concept]

Keyword's position in hierarchy(ies) :

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