" /> Glucarpidase - CISMeF





Preferred Label : Glucarpidase;

NCIt synonyms : Carboxypeptidase G2; CPG2; CPDG2; Poly(gamma-glutamic Acid) Endohydrolase; Pteroylpolygammaglutamyl Hydrolase; Acetylaspartylglutamate Dipeptidase;

NCIt related terms : carboxypeptidase-G2;

NCIt definition : A zinc-dependent enzyme isolated from a strain of the bacterium Pseudomonas. Because glucarpidase rapidly hydrolyzes methotrexate into inactive metabolites, it may be useful as a rescue agent for methotrexate-induced nephrotoxicity. In antibody-directed enzyme prodrug therapy (ADEPT), this agent is conjugated with an antibody that binds to a specific tumor cell type, allowing for glucarpidase-catalyzed activation of a co-administered prodrug at the site of the tumor.;

Alternative definition : NCI-GLOSS: A bacterial enzyme that breaks down proteins and other substances, including methotrexate. It is being studied in the treatment of toxic effects caused by methotrexate. It may also help activate certain drugs to kill cancer cells. It is a type of chemoprotective agent and a type of prodrug activator.;

UNII : 2GFP9BJD79;

CAS number : 9074-87-7;

Drug name : Voraxaze; Megludase;

Chemical formula : C20H20O4;

NSC code : 641273; 732443;

Codes from synonyms : CDR0000045384; 247;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
31/05/2025


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.