Talotrexin Ammonium

Preferred Label : Talotrexin Ammonium;

NCIt synonyms : 2-(((4S)-4-Carboxy-4-((4-(((2,4-diaminopteridin-6-yl)methyl)amino)benzoyl)amino)butyl)carbamoyl)benzoic Acid Monoammonium Salt;

NCIt definition : An ammonium salt of tallotrexin, an analogue of aminopterin with potential antineoplastic activity. As a folate antagonist, talotrexin binds to and inhibits the function of dihydrofolate reductase, resulting in the inhibition of folate metabolism, DNA synthesis, and cell division. Hydrosoluble, talotrexin is actively transported into cells by the reduced folate carrier (RFC) and, therefore, is unlikely to be associated with P-glycoprotein-mediated multidrug resistance.;

UNII : 686WJT9102;

InChIKey : CURXCENNYPPKOS-FYZYNONXSA-N;

CAS number : 648420-92-2;

Molecule name : PT-523;

Chemical formula : C27H27N9O6.H3N;

NSC code : 712783;

Details

Origin ID

C80159;

UMLS CUI

C2699886;

Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Dihydrofolate Reductase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Amino Acid Synthesis Inhibition [NCIt concept]
- Positive Regulation of Cell Death [NCIt concept]
- Purine Synthesis Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Talotrexin [NCIt concept]
has_target
- Dihydrofolate Reductase [NCIt concept]
is_salt_form_of
- Talotrexin [NCIt concept]

Keyword's position in hierarchy(ies) :

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