NCIt definition : An ammonium salt of tallotrexin, an analogue of aminopterin with potential antineoplastic
activity. As a folate antagonist, talotrexin binds to and inhibits the function of
dihydrofolate reductase, resulting in the inhibition of folate metabolism, DNA synthesis,
and cell division. Hydrosoluble, talotrexin is actively transported into cells by
the reduced folate carrier (RFC) and, therefore, is unlikely to be associated with
P-glycoprotein-mediated multidrug resistance.;
UNII : 686WJT9102;
InChIKey : CURXCENNYPPKOS-FYZYNONXSA-N;
CAS number : 648420-92-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 648420-92-2
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