Talotrexin - CISMeF

Preferred Label : Talotrexin;

NCIt synonyms : Talopterin; N(alpha)-(4-Amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine;

NCIt definition : An antimetabolite analogue of aminopterin with potential antineoplastic activity. As a folate antagonist, talotrexin binds to and inhibits the function of dihydrofolate reductase, resulting in the inhibition of folate metabolism, DNA synthesis, and cell division. Hydrosoluble, talotrexin is actively transported into cells by the reduced folate carrier (RFC) and, therefore, is unlikely to be associated with P-glycoprotein-mediated multidrug resistance.;

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of leukemia and some other types of cancer. It belongs to the family of drugs called antifolates.;

UNII : A8E516A20K;

InChIKey : NYQPLPNEESYGNO-IBGZPJMESA-N;

CAS number : 113857-87-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 113857-87-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : PT523;

Chemical formula : C27H27N9O6;

NSC code : 623017;

Codes from synonyms : CDR0000455149;

Details

Origin ID

C29341;

UMLS CUI

C1765332;

Automatic exact mappings (from CISMeF team)
- N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine [MeSH concept]
- N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- talotrexin [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- talotrexin [MeSH concept]
chemical_or_drug_affects_gene_product
- Dihydrofolate Reductase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Amino Acid Synthesis Inhibition [NCIt concept]
- Positive Regulation of Cell Death [NCIt concept]
- Purine Synthesis Inhibition [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Talotrexin Ammonium [NCIt concept]
is_free_acid_or_base_form_of
- Talotrexin Ammonium [NCIt concept]

Keyword's position in hierarchy(ies) :

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