" /> Pralatrexate - CISMeF





Preferred Label : Pralatrexate;

NCIt synonyms : N-(4-{1-[(2,4-Diaminopteridin-6-yl)methyl]but-3-yn-1-yl}benzoyl)-L-glutamic Acid; (2S)-2-[[4-[(1RS)-1-[(2, 4-Diaminopteridin-6-yl)methyl]but-3-ynyl]benzoyl]amino]pentanedioic Acid; 10-Propargyl-10-Deazaaminopterin; PDX; FOLOTYN;

NCIt related terms : FOLOTYN;

NCIt definition : A folate analogue inhibitor of dihydrofolate reductase (DHFR) exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intracellularly, this agent is highly polyglutamylated and competes for the folate binding site of DHFR, blocking tetrahydrofolate synthesis, which may result in depletion of nucleotide precursors; inhibition of DNA, RNA and protein synthesis; and apoptotic tumor cell death. Efficient intracellular polyglutamylation of pralatrexate results in higher intracellular concentrations compared to non-polyglutamylated pralatrexate, which is more readily effuxed by the MRP (multidrug resistance protein) drug efflux pump. RFC-1, an oncofetal protein expressed at highest levels during embryonic development, may be over-expressed on the cell surfaces of various cancer cell types.;

Alternative definition : NCI-GLOSS: A drug used in the treatment of peripheral T-cell lymphoma (a fast-growing form of non-Hodgkin lymphoma). It is also being studied in the treatment of other types of cancer. Pralatrexate may block the growth of cancer cells and cause them to die. It is a type of dihydrofolate reductase (DHFR) inhibitor.;

UNII : A8Q8I19Q20;

InChIKey : OGSBUKJUDHAQEA-WMCAAGNKSA-N;

CAS number : 146464-95-1;

Drug name : Folotyn; Difolta;

Codes from synonyms : CDR0000657510; CDR0000657511; CDR0000044880; 414;

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30/05/2025


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