Preferred Label : IGF-methotrexate Conjugate;
NCIt synonyms : 765IGF-MTX; IGF/MTX Conjugate;
NCIt definition : A conjugate containing the antimetabolite and antifolate agent methotrexate conjugated
to insulin-like growth factor (IGF), with potential antineoplastic activity. After
intravenous administration, the IGF moiety of the IGF-methotrexate conjugate binds
to and is internalized by IGF receptors (IGFR) on the surface of tumor cells. Following
cell entry, the methotrexate then binds to and inhibits the enzyme dihydrofolate reductase,
which catalyzes the conversion of dihydrofolate to tetrahydrofolate. This results
in both the inhibition of DNA and RNA synthesis and the induction of death in rapidly
dividing cells. Binding to IGFR can localize the cytotoxic effect of methotrexate
in tumor cells. This may increase its efficacy while decreasing its toxicity to normal,
healthy cells. IGFR is overexpressed on many types of cancer cells and has been implicated
in metastasis and resistance to apoptosis.;
Molecule name : IGF/MTX;
NCI Metathesaurus CUI : CL471770;
Origin ID : C113789;
UMLS CUI : C3827038;
Semantic type(s)
- concept_is_in_subset
- has_target
