" /> Capecitabine - CISMeF





Preferred Label : Capecitabine;

NCIt synonyms : 5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-cytidine;

NCIt related terms : Xeloda;

NCIt definition : A fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand. (NCI04);

Alternative definition : NCI-GLOSS: A drug used to treat stage III colon cancer in patients who had surgery to remove the cancer. It is also used to treat metastatic breast cancer that has not improved after treatment with certain other anticancer drugs. Xeloda is being studied in the treatment of other types of cancer. It is taken up by cancer cells and breaks down into 5-fluorouracil, a substance that kills tumor cells. Xeloda is a type of antimetabolite.;

UNII : 6804DJ8Z9U;

InChIKey : GAGWJHPBXLXJQN-UORFTKCHSA-N;

CAS number : 154361-50-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 154361-50-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Xeloda;

Molecule name : Ro 09-1978/000;

Chemical formula : C15H22FN3O6;

NSC code : 712807;

ChEBI ID : CHEBI:31348;

Codes from synonyms : 50091; CDR0000508532; CDR0000045565; 86;

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15/05/2024


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