" /> Floxuridine - CISMeF





Preferred Label : Floxuridine;

NCIt synonyms : Fluorodeoxyuridine; Fluorouridine Deoxyribose; Floxuridin; 5-Fluorouracil Deoxyriboside; FUdR; 2'-Deoxy-5-fluorouridine; 5-Fluoro-2'-deoxy-beta-uridine; FDUR; 1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil; 2-Deoxy-5-fluorouridine; 5-Fluorouridine Deoxyribose; Fluoruridine Deoxyribose; 5-Fluorodeoxyuridine;

NCIt related terms : 5-Fluoro-2'-deoxyuridine; 5-FUDR;

NCIt definition : A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity. This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. (NCI04);

Alternative definition : NCI-GLOSS: A drug used in the treatment of cancer. It is a type of antimetabolite.;

UNII : 039LU44I5M;

InChIKey : ODKNJVUHOIMIIZ-RRKCRQDMSA-N;

CAS number : 50-91-9;

Molecule name : WR-138720; WR 138720;

Chemical formula : C9H11FN2O5;

NSC code : 27640;

ChEBI ID : CHEBI:60761;

Codes from synonyms : NSC0027640; CDR0000045198; 07814; 222;

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30/05/2025


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